Reinvestigation of the Cyclic Condensation of Adiponitrile
Reinvestigation of the Cyclic Condensation of Adiponitrile
复制标题
己二腈循环缩合反应的再研究
DOI：
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发表时间：
1971
期刊：
影响因子：
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通讯作者：
Kosuke Yamamoto
中科院分区：
文献类型：
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作者：
Kosuke Yamamoto
将己二腈的索普反应产物1-氨基-2-氰基环戊烯-1（2）与另一种己二腈缩合，得到4-氨基-6，7-二氢-5H-环戊并[d]嘧啶-2-戊腈（4）和1，4-二（4-氨基-6，7-二氢-5H-环戊并[d]嘧啶）丁烷（5）的混合物。在非均相催化的情况下，以50 - 70%的产率获得（2）。(4)水解生成2，4-二羟基-6，7-二氢-5H-环戊二烯并[d]嘧啶-2-戊酸，结果表明氰基和氨基均水解。
1-Amino-2-cyanocyclopentene-1 (2), which is a Thorpe reaction product of adiponitrile, was condensed with another adiponitrile, and a mixture of 4-amino-6, 7-dihydro-5H-cyclopenta [d] pyrimidine-2-valeronitrile (4) and 1, 4-di (4-amino-6, 7-dihydro-5H-cyclopenta [d] pyrimidil) butane (5) was obtained. In case of heterogeneous catalysis, (2) was obtained in 5070% yield.(4) was hydrolyzed to 2, 4-dihydroxy-6, 7-dihydro-5H-cyclopenta [d] pyrimidine-2-valeric acid, the results show that both the cyano group and the amino group were hydrolyzed.