CARNITINE METABOLISM IN NORMAL-WEIGHT AND OBESE HUMAN-SUBJECTS DURING FASTING
CARNITINE METABOLISM IN NORMAL-WEIGHT AND OBESE HUMAN-SUBJECTS DURING FASTING
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DOI：
10.1152/ajpendo.1980.238.5.e409
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
GENUTH, SM
中科院分区：
文献类型：
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作者：
HOPPEL, CL;GENUTH, SM
通过测定血浆和尿液中的肉毒碱及其酰基衍生物，研究了正常体重和肥胖受试者的肉毒碱代谢。当第一次喂等热量，低肉毒碱饮食，两组显示血浆总肉毒碱减少，主要是由于游离肉毒碱分数减少。尿游离肉毒碱排泄量明显下降。当空腹制定血浆总肉毒碱浓度增加。这是一个短链和长链酰基肉毒碱和游离肉毒碱延迟减少快速增加的净结果。尿中短链酰基肉毒碱的排泄量增加平行于血浆浓度的上升，而游离肉毒碱排泄量首先下降，然后趋于略有增加。血浆和尿短链酰基肉毒碱与β-羟基丁酸盐。所有这些变化都被逆转的再喂养的肥胖，即使是低肉毒碱低热量摄入。肥胖受试者发展高酮血症显着更慢，比体重正常的受试者，但实质上表现出相同的变化幅度和方向的肉毒碱及其代谢产物。
Carnitine metabolism was studied in normal-weight and obese subjects by measurement of carnitine and its acyl derivatives in plasma and urine. When first fed an isocaloric, low-carnitine diet, both groups showed a decrease in plasma total carnitine, primarily due to a decrease in the free carnitine fraction. Urinary free carnitine excretion fell significantly. When fasting was instituted plasma total carnitine concentration increased. This was the net result of a rapid increase in short-chain and long-chain acylcarnitine and a delayed decrease in free carnitine. Urinary excretion of short-chain acylcarnitines increased parallel to rising plasma concentrations whereas free carnitine excretion first decreased and then tended to increase slightly. Plasma and urinary short-chain acylcarnitine correlated with .beta.-hydroxybutyrate. All of these changes were reversed by refeeding in the obese even with a low-carnitine hypocaloric intake. Obese subjects developed hyperketonemia significantly more slowly than did normal-weight subjects, yet substantially demonstrated the same changes in magnitude and direction in carnitine and its metabolites.