Neural correlates of unpredictability in behavioral patterns of wild-type and R6/2 mice.
Neural correlates of unpredictability in behavioral patterns of wild-type and R6/2 mice.
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DOI：
10.4161/cib.19782
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发表时间：
2012-05-01
影响因子：
--
通讯作者：
Rebec GV
中科院分区：
文献类型：
--
作者：
Hong SL;Barton SJ;Rebec GV
本文扩展了最近的研究结果，即纹状体活动的动态模式与野生型和转基因小鼠（R6/2）的运动和探索模式之间的联系，这些小鼠模拟了亨廷顿病（HD），一种致命的遗传性神经系统疾病。在这里，以HD为背景，我们进一步发展了大脑和行为中的熵守恒概念。特别是，我们提出熵守恒可以作为一个规则，指导重新分配大脑活动动力学的过程，以改变行为，允许适应不断变化的外部环境。这一概念进一步与最近对人类衰老的神经影像学研究联系起来，在我们最近的熵守恒发现和现存文献之间建立了一座新的桥梁。
This paper expands on recent findings that link dynamic patterns of striatal activity with patterns of movement and exploration in wild-type and transgenic mice (R6/2) that model Huntington disease (HD), a fatally inherited neurological condition. Here, with HD as a backdrop, we further develop the concept of entropy conservation in brain and behavior. In particular, we propose that entropy conservation could serve as a rule that guides the process of redistributing brain activity dynamics in order to alter behavior, allowing the adaptation to an ever-changing external environment. This concept is further linked to recent neuroimaging studies in human aging, building a new bridge between our recent findings of entropy conservation and the extant literature.