Influenza-associated myositis in children
Influenza-associated myositis in children
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DOI：
10.1007/s15010-004-4003-2
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发表时间：
2004-08-01
期刊：
影响因子：
7.5
通讯作者：
Aebi, C
中科院分区：
文献类型：
--
作者：
Agyeman, P;Duppenthaler, A;Aebi, C
背景：流感相关性肌炎（IAM）是儿童流感病毒感染的一种罕见且知之甚少的并发症。本研究的目的是描述5例IAM和审查文学IAM在children.Patients和方法：我们进行了回顾性分析的情况下，IAM诊断在瑞士两所大学的儿童医院在连续两个流感季节。结果进行了比较，39个个案报告和5个出版物总结了额外的272例确定的医学在线图书馆（MEDLINE）search.Results：总体而言，316例进行了分析。IAM通常发生在学龄儿童中，具有2：1的伴侣优势。分别在76%和24%的病例中鉴定出流感B和A病毒。流感发作和IAM发作之间的中位间隔为3天（范围0-18）。小腿肌肉单独受累或合并其他肌群受累的分别占69%和31%。血肌酸磷酸激酶（CPK）浓度总是升高。至临床恢复的中位持续时间为3天（范围1-30）。横纹肌溶解症发生在10 316例（3%），更常见于女孩（80%），更经常与甲型流感（86%），并导致肾功能衰竭8例（80%.Conclusion：IAM的临床和实验室检查结果是高度特征性的，并允许在流感季节快速诊断。
Background: Influenza-associated myositis (IAM) is an infrequent and poorly known complication of influenza virus infection in children. The aim of this study was to describe five cases of IAM and to review the Literature on IAM in children.Patients and Methods: We conducted a retrospective analysis of cases of IAM diagnosed at two university children's hospitals in Switzerland during two consecutive influenza seasons. Findings were compared with 39 individual case reports and five publications summarizing an additional 272 cases identified by a medical online Library (MEDLINE) search.Results: Overall, 316 cases were analyzed. IAM typically occurred in school-aged children with a 2:1 mate predominance. Influenza B and A viruses were identified in 76% and 24% of cases, respectively. The median interval between onset of influenza and onset of IAM was 3 days (range 0-18). The calf muscles were involved alone or together with other muscle groups in 69% and 31% of cases, respectively. Blood creatine phosphokinase (CPK) concentration was invariably elevated. Median duration to clinical recovery was 3 days (range 1-30). Rhabdomyolysis occurred in ten of 316 patients (3%), was more common in girls (80%), more often associated with influenza A (86%), and led to renal failure in eight patients (80%).Conclusion: Clinical and laboratory findings of IAM are highly characteristic and allow a rapid diagnosis during the influenza season.