Effects of Depressive Symptoms, Feelings, and Interoception on Reward-Based Decision-Making: Investigation Using Reinforcement Learning Model
Effects of Depressive Symptoms, Feelings, and Interoception on Reward-Based Decision-Making: Investigation Using Reinforcement Learning Model
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DOI：
10.3390/brainsci10080508
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发表时间：
2020-08
期刊：
影响因子：
3.3
通讯作者：
Hiroyoshi Ogishima;S. Maeda;Yuki Tanaka;H. Shimada
中科院分区：
文献类型：
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作者：
Hiroyoshi Ogishima;S. Maeda;Yuki Tanaka;H. Shimada
背景：在这项研究中，我们研究了学习率、记忆率、探索率等基于奖励的决策与内感受和感受方面的抑郁相关主观情绪体验之间的关系，以了解基于奖励的决策在抑郁症中是如何受到损害的。方法：将52名大学生随机分为实验组和对照组。为了操纵内感受，实验组的参与者被指示将他们的内部躯体感觉调整到显示器上呈现的皮肤电导反应波形。对照组的参与者仅被指示保持放松。在操纵之前和之后，参与者完成了概率逆向学习任务，以使用强化学习模型评估基于奖励的决策。同样，参与者完成了探针检测任务、心跳检测任务和自评量表。结果：内感受的实验操作并不成功。在基线测试中，强化学习模型表明探索率与抑郁症状之间存在轻微显着相关性。然而，探索率与较低的内感受注意力和较高的抑郁感显着相关。结论：研究结果表明，情境特征可能与奖励探索密切相关，并强调了情感过程干预可能影响抑郁症患者基于奖励的决策这一具有临床意义的可能性。
Background: In this study, we examined the relationships between reward-based decision-making in terms of learning rate, memory rate, exploration rate, and depression-related subjective emotional experience, in terms of interoception and feelings, to understand how reward-based decision-making is impaired in depression. Methods: In all, 52 university students were randomly assigned to an experimental group and a control group. To manipulate interoception, the participants in the experimental group were instructed to tune their internal somatic sense to the skin-conductance-response waveform presented on a display. The participants in the control group were only instructed to stay relaxed. Before and after the manipulation, the participants completed a probabilistic reversal-learning task to assess reward-based decision-making using reinforcement learning modeling. Similarly, participants completed a probe-detection task, a heartbeat-detection task, and self-rated scales. Results: The experimental manipulation of interoception was not successful. In the baseline testing, reinforcement learning modeling indicated a marginally-significant correlation between the exploration rate and depressive symptoms. However, the exploration rate was significantly associated with lower interoceptive attention and higher depressive feeling. Conclusions: The findings suggest that situational characteristics may be closely involved in reward exploration and highlight the clinically-meaningful possibility that intervention for affective processes may impact reward-based decision-making in those with depression.