Androgen receptor as a targeted therapy for breast cancer.
Androgen receptor as a targeted therapy for breast cancer.
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DOI：
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发表时间：
2012
影响因子：
5.3
通讯作者：
J. Garay;B. Park
中科院分区：
文献类型：
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作者：
J. Garay;B. Park
乳腺癌在女性中发病率很高，鉴于这一事实，乳腺癌研究的主要焦点是雌激素受体 α (ER) 信号传导的研究。然而，众所周知，雄激素在正常乳腺生理学中发挥着重要作用，因此雄激素受体 (AR) 信号传导越来越被认为是乳腺癌发生的重要因素。此外，乳腺癌中 AR 的高表达频率使其成为有吸引力的治疗靶点，但利用 AR 进行治疗的能力一直很困难。在这里，我们回顾了雄激素/抗雄激素疗法在乳腺癌中的历史应用、体外准确模拟核激素受体信号传导的挑战，以及乳腺癌中 AR 的存在和预后意义。
Breast cancer occurs at a high frequency in women and, given this fact, a primary focus of breast cancer research has been the study of estrogen receptor α (ER) signaling. However, androgens are known to play a role in normal breast physiology and therefore androgen receptor (AR) signaling is becoming increasingly recognized as an important contributor towards breast carcinogenesis. Moreover, the high frequency of AR expression in breast cancer makes it an attractive therapeutic target, but the ability to exploit AR for therapy has been difficult. Here we review the historical use of androgen/anti-androgen therapies in breast cancer, the challenges of accurately modeling nuclear hormone receptor signaling in vitro, and the presence and prognostic significance of AR in breast cancer.