Decreased Reelin Expression in the Left Prefrontal Cortex (BA9) in Chronic Schizophrenia Patients
Decreased Reelin Expression in the Left Prefrontal Cortex (BA9) in Chronic Schizophrenia Patients
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DOI：
10.1159/000337129
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发表时间：
2012-01-01
影响因子：
3.2
通讯作者：
Falkai, Peter
中科院分区：
文献类型：
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作者：
Habl, Gregor;Schmitt, Andrea;Falkai, Peter
背景：Reelin受表观遗传控制，据报道在精神分裂症患者的皮质区域减少。研究方法：为了确定是否在精神分裂症患者的特定皮质、海马或丘脑区域中改变了reelin的表达，我们在一项对老年精神分裂症患者和未受影响的对照组进行的死后研究中测量了reelin在两个半球区分灰质和白色物质的基因表达。我们比较了12名精神分裂症患者和13名正常人的大脑死后样本（背外侧前额叶皮层BA 9和BA 46、上级颞叶皮层BA 22、内嗅皮层BA 28、感觉皮层BA 1 -3、海马、CA 4、丘脑背内侧核），通过原位杂交研究了两个半球灰质和白色物质中的reelin基因表达。结果如下：与对照组相比，精神分裂症患者的左前额区（BA 9）显示，在白色中reelin-mRNA的表达减少了29.1%（p = 0.022），在灰质中减少了13.6%（p = 0.007）。所审查的其他区域均未显示出任何统计上的显著差异。结论：由于reelin是负责迁移和突触的形成，reelin在精神分裂症患者的左前额叶区的基因表达减少，神经元迁移和突触可塑性的神经发育缺陷。然而，我们的研究小组很小，结果应该使用更大的样本进行验证。版权所有（C）2012 S. Karger AG，巴塞尔
Background: Reelin is under epigenetic control and has been reported to be decreased in cortical regions in schizophrenia. Methods: To establish if expression of reelin is altered in specific cortical, hippocampal or thalamic regions of schizophrenia patients, we measured gene expression of reelin in a postmortem study of elderly patients with schizophrenia and non-affected controls in both hemispheres differentiating between gray and white matter. We compared cerebral postmortem samples (dorsolateral prefrontal cortex BA9 and BA46, superior temporal cortex BA22, entorhinal cortex BA28, sensoric cortex BA1-3, hippocampus, CA4, mediodorsal nucleus of the thalamus) from 12 schizophrenia patients with 13 normal subjects investigating gene expression of reelin in the gray and white matter of both hemispheres by in situ-hybridization. Results: The left prefrontal area (BA9) of schizophrenia patients revealed a decreased expression of reelin-mRNA of 29.1% in the white (p = 0.022) and 13.6% in the gray matter (p = 0.007) compared to the control group. None of the other regions examined showed any statistically significant differences. Conclusion: Since reelin is responsible for migration and synapse formation, the decreased gene expression of reelin in the left prefrontal area of schizophrenia patients points to neurodevelopmental deficits in neuronal migration and synaptic plasticity. However, our study group was small, and results should be verified using larger samples. Copyright (C) 2012 S. Karger AG, Basel