The prevalence of Lynch syndrome in women with endometrial cancer: a systematic review protocol.
The prevalence of Lynch syndrome in women with endometrial cancer: a systematic review protocol.
复制标题
子宫内膜癌女性林奇综合征的患病率：系统审查方案。
DOI：
10.1186/s13643-018-0792-8
复制
发表时间：
2018-08-16
影响因子：
3.7
通讯作者：
Crosbie EJ
中科院分区：
文献类型：
--
作者：
Ryan NAJ;Blake D;Cabrera-Dandy M;Glaire MA;Evans DG;Crosbie EJ
林奇综合征是最常见的遗传性癌症综合征，易患多种不同的癌症，主要是结直肠癌和子宫内膜癌。Lynch综合征的早期诊断使结直肠监测成为可能，这已被证明通过检测和切除癌前息肉和更早发现侵袭性疾病来挽救生命。子宫内膜癌通常是女性的前哨癌，它为诊断Lynch综合征提供了机会，从而使结直肠监测以及其他家庭成员的Lynch综合征级联检测成为可能。这些潜在的好处导致了对患有子宫内膜癌的女性进行普遍筛查林奇综合征的呼吁，这一做法现在在结直肠癌中很常见。然而，医疗保健提供者和临床医生受到对患有子宫内膜癌的女性中林奇综合征患病率缺乏了解的限制，估计差异高达1%-10%。这项研究的目的是对现有文献进行系统回顾和荟萃分析，以评估子宫内膜癌妇女中Lynch综合征的患病率，为这一讨论提供信息。将通过Ovid平台系统地搜索Medline、Embase、Cochrane中央对照试验注册中心、Cochrane方法学注册中心、NHS健康与技术评估数据库和科学网络，以查找相关研究。两位作者将独立审查标题和摘要，不一致之处由第三位作者解决。数据提取将完成，以记录人口统计学、病理学和临床数据，以及用于估计患有子宫内膜癌的妇女的林奇综合征患病率的诊断方法。偏差将使用纽卡斯尔-渥太华量表和国际科克伦合作量表进行评估和记录。根据数据的异质性，我们的目标是在亚组分析的基础上产生累积发病率，以调查次要结果。这项系统性综述的目的是对患有子宫内膜癌的妇女中林奇综合征的患病率提供一个强有力的估计。这将使资源分配和关于筛查所有患有子宫内膜癌的妇女或某些妇女是否适合林奇综合征的决策成为可能。这样的政策可以使妇女更早地诊断出林奇综合征，并通过应用结直肠癌监测，改善她们的生存结果。该系统评价已在Propero上注册(参考文献CRD42017081707)。
Lynch syndrome is the most common inherited cancer syndrome, which predisposes individuals to a number of different cancers, principally colorectal and endometrial cancer. The early diagnosis of Lynch syndrome enables colorectal surveillance, which has been shown to save lives through the detection and removal of premalignant polyps and earlier detection of invasive disease. Endometrial cancer, which is often the sentinel cancer in women, provides an opportunity to diagnose Lynch syndrome and thus enable colorectal surveillance as well as the cascade testing for Lynch syndrome in other family members. These potential benefits have led to a call for the universal screening of women with endometrial cancer for Lynch syndrome, a practice that is now commonplace in colorectal cancer. Healthcare providers and clinicians are however restricted by insufficient knowledge about the prevalence of Lynch syndrome in women with endometrial cancer, with estimates varying as widely as 1–10%. The aim of this study is to perform a systematic review with a meta-analysis of the current literature base in order to estimate the prevalence of Lynch syndrome among women with endometrial cancer to inform this discussion. Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Methodology Register, NHS Health and Technology Assessment Database and the Web of Science will be systematically searched for relevant studies via the Ovid platform. Two authors will review the titles and abstracts independently, with discrepancy settled by a third author. Data extraction will be completed to record demographic, pathological and clinical data, as well as the diagnostic methods used for estimating the prevalence of Lynch syndrome in women with endometrial cancer. Bias will be assessed and recorded using the Newcastle-Ottawa Scale and that of the International Cochrane Collaboration. Dependent on the heterogeneity of the data, we aim to produce a cumulative incidence in addition to subgroup analyses as to investigate secondary outcomes. The aim of this systematic review is to provide a robust estimate of the prevalence of Lynch syndrome in women with endometrial cancer. This will enable resource allocation and decision-making regarding the appropriateness of screening all women, or certain women, with endometrial cancer for Lynch syndrome. Such a policy could enable the earlier diagnosis of Lynch syndrome in women and, through the application of colorectal cancer surveillance, improve their survival outcomes. This systematic review has been registered on PROSPERO (ref CRD42017081707).
登录
查看更多内容
影响因子：
3.3
作者：
Mas-Moya, Jenny;Dudley, Beth;Pai, Reetesh K.
通讯作者：
Pai, Reetesh K.
影响因子：
24.5
作者：
Møller P;Seppälä T;Bernstein I;Holinski-Feder E;Sala P;Evans DG;Lindblom A;Macrae F;Blanco I;Sijmons R;Jeffries J;Vasen H;Burn J;Nakken S;Hovig E;Rødland EA;Tharmaratnam K;de Vos Tot Nederveen Cappel WH;Hill J;Wijnen J;Green K;Lalloo F;Sunde L;Mints M;Bertario L;Pineda M;Navarro M;Morak M;Renkonen-Sinisalo L;Frayling IM;Plazzer JP;Pylvanainen K;Sampson JR;Capella G;Mecklin JP;Möslein G;Mallorca Group (http://mallorca-group.eu)
通讯作者：
Mallorca Group (http://mallorca-group.eu)
影响因子：
3.6
作者：
Huxley，Nicola;Jones-Hughes，Tracey;Mujica-Mota，Ruben
通讯作者：
Mujica-Mota，Ruben
影响因子：
5.6
作者：
Rabban, Joseph T.;Calkins, Sarah M.;Chen, Lee-may
通讯作者：
Chen, Lee-may
DOI：
10.1200/jco.2015.63.9518
发表时间：
2015-12-20
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Goodfellow PJ;Billingsley CC;Lankes HA;Ali S;Cohn DE;Broaddus RJ;Ramirez N;Pritchard CC;Hampel H;Chassen AS;Simmons LV;Schmidt AP;Gao F;Brinton LA;Backes F;Landrum LM;Geller MA;DiSilvestro PA;Pearl ML;Lele SB;Powell MA;Zaino RJ;Mutch D
通讯作者：
Mutch D