Sex differences in pediatric bipolar disorder
Sex differences in pediatric bipolar disorder
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DOI：
10.4088/jcp.v68n1016
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发表时间：
2007-10-01
影响因子：
5.3
通讯作者：
Findling, Robert L.
中科院分区：
文献类型：
--
作者：
Duax, Jeanne M.;Youngstrom, Eric A.;Findling, Robert L.
目的：探讨儿童双相情感障碍在抑郁和躁狂症状类型和严重程度方面的性别差异。参与者为760名青年（5-17岁）及其法律的监护人。参与者是一个更大的门诊评估协议的一部分，丰富了双相情感障碍。使用学龄儿童情感障碍和精神分裂症量表-流行病学版对青少年进行DSM-IV诊断评估。他们目前的情绪状态，确定使用青年躁狂量表和儿童抑郁量表修订版。结果：387例（51%）符合DSM-IV诊断标准。结果显示，双相谱系障碍或任何双相亚型的发病率没有性别差异。在呈现情绪状态方面发现了性别差异：男孩呈现出更高的躁狂情绪，女孩呈现出更高的抑郁情绪。年龄较大的孩子也比年龄较小的孩子更有可能表现出更高水平的抑郁情绪。有没有年龄差异的躁狂moods.Conclusion水平：这项研究强调了如何双相情感障碍可以表现出不同的女孩和男孩，尽管诊断率相等。重要的是，临床医生要考虑到全方位的情绪状态，以准确地诊断和治疗儿童。未来的研究需要评估遗传学，青春期，认知方式和环境因素在女孩和男孩的躁狂和抑郁症的表达中发挥的作用。
Objective: To explore sex differences in pediatric bipolar disorder in terms of subtype and severity of depressive and manic symptornatology.Method. Participants were 760 youth (aged 5-17 years) and their legal guardians. Participants were part of a larger outpatient assessment protocol enriched for bipolar disorder. Youth were assessed for DSM-IV diagnoses using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Epidemiologic Version. Their presenting mood state was determined using the Young Mania Rating Scale and the Children's Depression Rating Scale-Revised. The study was conducted from January 1996 to February 2003.Results: 387 youth (5 1 %) met DSM-IV criteria for diagnoses of bipolar spectrum disorders. Results showed no sex differences in rates of bipolar spectrum disorders or any of the bipolar subtypes. Sex differences were found with regard to presenting mood states: boys presented with higher rates of manic mood, and girls presented with higher rates of depressed mood. Older children were also more likely than younger children to exhibit higher levels of depressed mood. There were no age differences in levels of manic mood.Conclusion: This study highlights how bipolar disorder can manifest itself differently among girls and boys despite equivalent rates of diagnosis. It is important for clinicians to consider the full range of mood states in order to accurately diagnose and treat children. Future research is needed to assess the roles that genetics, puberty, cognitive styles, and environmental factors play in the expression of mania and depression in girls and boys over the course of their development.