A lactate-derived chiral aldehyde for determining the enantiopurity of enantioenriched primary amines.
A lactate-derived chiral aldehyde for determining the enantiopurity of enantioenriched primary amines.
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DOI：
10.1039/c5ob01398d
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发表时间：
2015-08
影响因子：
3.2
通讯作者：
Samantha M. Gibson;R. Lanigan;L. Benhamou;A. Aliev;T. Sheppard
中科院分区：
文献类型：
--
作者：
Samantha M. Gibson;R. Lanigan;L. Benhamou;A. Aliev;T. Sheppard
在本文中，我们描述了使用从乳酸酯衍生的手性醛来测定伯胺的对映纯度，通过形成非对映异构体亚胺。结果表明，该方法可重复性地测定多种手性胺的对映纯度。醛的两种对映体都可以用两步从市售材料中制备。
In this paper we describe the use of a chiral aldehyde derived from lactate esters for determining the enantiopurity of primary amines, via the formation of diastereomeric imines. The method was shown to be suitable for reproducibly determining the enantiopurity of a diverse set of chiral amines. Both enantiomers of the aldehyde can be prepared in two steps from commercially available materials.