Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
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DOI：
10.1126/science.1078231
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发表时间：
2003-02-14
期刊：
影响因子：
56.9
通讯作者：
Medzhitov, R
中科院分区：
文献类型：
--
作者：
Pasare, C;Medzhitov, R
Toll样受体（TLRs）通过抗原呈递细胞（APCs）控制适应性免疫应答的激活。然而，适应性免疫应答的启动也受调节性T细胞（T - R细胞）的控制，调节性T细胞的作用是防止自身反应性T细胞的激活。在此我们描述了一种由Toll样受体介导的免疫诱导的第二种机制，它不依赖于对共刺激的影响。Toll通路的微生物诱导阻断了CD4(+)CD25(+)调节性T细胞的抑制作用，从而允许病原体特异性适应性免疫应答的激活。这种抑制活性的阻断部分依赖于白细胞介素 - 6，白细胞介素 - 6是由Toll样受体在识别微生物产物时诱导产生的。
Toll-like receptors (TLRs) control activation of adaptive immune responses by antigen-presenting cells (APCs). However, initiation of adaptive immune responses is also controlled by regulatory T cells (T-R cells), which act to prevent activation of autoreactive T cells. Here we describe a second mechanism of immune induction by TLRs,which is independent of effects on costimulation. Microbial induction of the Toll pathway blocked the suppressive effect of CD4(+)CD25(+) T-R cells, allowing activation of pathogen-specific adaptive immune responses. This block of suppressor activity was dependent in part on interleukin-6, which was induced by TLRs upon recognition of microbial products.