SLEEP-DISORDERED BREATHING IN MARFANS-SYNDROME
SLEEP-DISORDERED BREATHING IN MARFANS-SYNDROME
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DOI：
10.1164/ajrccm/147.3.645
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发表时间：
1993-03-01
期刊：
影响因子：
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通讯作者：
SULLIVAN, CE
中科院分区：
文献类型：
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作者：
CISTULLI, PA;SULLIVAN, CE
我们研究了马凡氏综合征患者的睡眠呼吸障碍的患病率，观察阻塞性睡眠呼吸暂停（OSA）的患者与这种情况。我们研究了25例符合马凡氏综合征诊断标准的患者（12例男性和13例女性，平均年龄31.9 ± 2.8岁）。随机招募了21名患者。我们将他们与12名年龄、身高和体重相匹配的对照组进行了比较。在病史上，25例患者中有23例有不同程度的打鼾，21例有轻度至中度日间嗜睡。标准夜间多导睡眠图显示，25例患者中有16例（64%）的呼吸暂停/呼吸不足指数（AHI）大于5，平均值为20 +/- 3，平均最低血氧饱和度为86 +/-2%。只有一名对照受试者的AHI > 5，该组的平均AHI为2 +/- 1（p = 0.0005）。呼吸暂停和呼吸不足本质上是阻塞性的。我们的结论是，有一个高患病率的睡眠呼吸障碍的马凡氏综合征患者，因此，OSA的症状和体征，应寻求在所有这样的患者。
We studied the prevalence of sleep-disordered breathing in patients with Marfan's syndrome after observing obstructive sleep apnea (OSA) in a patient with this condition. We studied 25 patients (12 men and 13 women with a mean age of 31.9 +/- 2.8 yr) who fulfilled the diagnostic criteria for Marfan's syndrome. Twenty-one of the patients were randomly recruited. We compared them with 12 age-, height-, and weight-matched control subjects. On history, 23 of 25 patients snored to some degree, and 21 of 25 had mild to moderate daytime hypersomnolence. Standard nocturnal polysomnography revealed that 16 of 25 (64%) patients had an apnea/hypopnea index (AHI) greater than 5, with a mean of 20 +/- 3, and a mean minimal oxyhemoglobin saturation of 86 +/- 2%. Only one control subject had an AHI > 5, and the mean AHI for the group was 2 +/- 1 (p = 0.0005). Apneas and hypopneas were obstructive in nature. We conclude that there is a high prevalence of sleep-disordered breathing in patients with Marfan's syndrome, and that therefore the symptoms and signs of OSA should be sought in all such patients.