AGE-RELATED CHANGE OF DISTRIBUTION OF IMMUNOGLOBULIN CONTAINING CELLS IN HUMAN-BONE MARROW - CHANGES IN PATIENTS WITH BENIGN MONOCLONAL GAMMOPATHY AND MULTIPLE-MYELOMA
AGE-RELATED CHANGE OF DISTRIBUTION OF IMMUNOGLOBULIN CONTAINING CELLS IN HUMAN-BONE MARROW - CHANGES IN PATIENTS WITH BENIGN MONOCLONAL GAMMOPATHY AND MULTIPLE-MYELOMA
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DOI：
10.1007/bf00694890
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
HATAKEYAMA, S
中科院分区：
文献类型：
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作者：
SUZUKI, K;HIROKAWA, K;HATAKEYAMA, S
用石蜡切片法对人骨髓中含IG细胞的数量和分布方式进行了免疫化学研究。在没有特定疾病的个体中，骨髓中含有IG的细胞/单位视野的数量随着年龄的增长而增加，直到30岁，此后趋于平稳。Ig-G和Ig-A的增加幅度很大，但Ig-M的增加幅度很小。骨髓中含有Ig-G和Ig-M的细胞数量的这种年龄相关变化几乎与血清Ig-G和Ig-M水平的年龄相关变化相当。骨髓含Ig-A细胞的增龄性增高幅度明显高于血清Ig-A水平。含IG细胞的簇形成在发生率和大小方面均随年龄增加。本文提出了良性单克隆丙种球蛋白病（BMG）与多发性骨髓瘤（MM）的鉴别要点。结果表明：1. BMG患者血清M组分水平与单位视野平均IG阳性细胞数的比值高于MM患者，MM患者单位视野IG阳性细胞数大于50个，而BMG患者单位视野Ig阳性细胞数小于20个，MM患者胞质狭窄的小IG阳性细胞多于BMG患者。
The number and mode of distribution of Ig containing cells in human bone marrow were investigated immunohistochemically using paraffin sections of bone marrow aspirates. In individuals without specific diseases, the number of Ig containing cells/unit field in bone marrow increased with advancing age until the 3rd decade and leveled off thereafter. The magnitude of the increase was great for Ig-G and Ig-A, but very slight for Ig-M. Such age-related change in the number of Ig-G and Ig-M containing cells in bone marrow was almost comparable to the age-related change of serum level of Ig-G and Ig-M. The magnitude of age-related increase of Ig-A containing cells in bone marrow was apparently higher than that of the serum level of Ig-A. Cluster formation of Ig containing cells increased with age in terms of both incidence and size. Three points were suggested for differentiation of benign monoclonal gammopathy (BMG) from multiple myeloma (MM). First, the ratio of serum level of M-component divided by the average number of Ig containing cells/unit field was higher in BMG than in MM; the number of cells/cluster of Ig containing cells was more than 50 in MM, but that in BMG less than 20; the small Ig globulin containing cells with narrow cytoplasm were more prominent in MM than in BMG.