One-pot facile preparation of PEG-modified PLGA nanoparticles: Effects of PEG and PLGA on release properties of the particles
One-pot facile preparation of PEG-modified PLGA nanoparticles: Effects of PEG and PLGA on release properties of the particles
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DOI：
10.1016/j.colsurfa.2015.01.011
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发表时间：
2015-03
期刊：
影响因子：
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通讯作者：
Nao Yoneki;T. Takami;Tomoki Ito;R. Anzai;K. Fukuda;Keita Kinoshita;Seiichi Sonotaki;Y. Murakami-
中科院分区：
文献类型：
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作者：
Nao Yoneki;T. Takami;Tomoki Ito;R. Anzai;K. Fukuda;Keita Kinoshita;Seiichi Sonotaki;Y. Murakami-
我们在这里展示了一种新的“嵌段共聚物辅助”乳化/蒸发方法，一锅简便地制备聚乙二醇（PEG）修饰聚丙交酯-共聚物-羟基乙酸酯（PLGA）纳米颗粒。在本文中，我们阐明了聚合物改性剂和成颗粒疏水聚合物的制备条件和结构性质对聚乙二醇修饰的PLGA纳米颗粒性能的影响。我们首先澄清了PLGA的浓度、有机溶剂与PVA溶液的体积比以及搅拌速率是影响纳米颗粒直径的主要因素。在优化条件下成功制备了直径约为200 nm的纳米颗粒。聚乙二醇-聚乳酸嵌段共聚物的添加量和组成对纳米粒子的表面电荷有影响。最后，我们澄清了嵌段共聚物的组成和分子量对peg修饰纳米颗粒的释放性能有很大影响。
We show here a one-pot facile preparation of poly(ethylene glycol) (PEG)-modified poly(lactide-co-glycolide) (PLGA) nanoparticles by means of a novel “block copolymer-assisted” emulsification/evaporation method. In the present article, we clarified the effects of preparation conditions and the structural properties of both polymeric modifiers and particle-forming hydrophobic polymers on the properties of the PEG-modified PLGA nanoparticles. We first clarified that the concentration of PLGA, the volume ratio of an organic solvent to a PVA solution, and a stirring rate were major factors affecting the diameter of the nanoparticles. We successfully prepared the nanoparticles, with a diameter of approximately 200 nm under the optimized conditions. The additive amount and the composition of PEG–PLA block copolymers affected the surface charge of the nanoparticles. Finally, we clarified that the compositions and molecular weights of the block copolymers greatly affected the release properties of PEG-modified nanoparticles.