Palladium-catalyzed cross-coupling of N-benzenesulfonyl-3,4-dibromopyrrole and its application to the total syntheses of lamellarins O, P, Q, and R
Palladium-catalyzed cross-coupling of N-benzenesulfonyl-3,4-dibromopyrrole and its application to the total syntheses of lamellarins O, P, Q, and R
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DOI：
10.1016/j.tet.2007.10.105
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发表时间：
2008-01-07
期刊：
影响因子：
2.1
通讯作者：
Iwao, Masatomo
中科院分区：
文献类型：
--
作者：
Fukuda, Tsutomu;Sudo, Ei-ichi;Iwao, Masatomo
钯催化的 N-苯磺酰基-3,4-二溴吡咯与各种芳基硼酸的 Suzuki-Miyaura 偶联以高产率得到相应的 3,4-二芳基吡咯。 3,4-差异芳基化吡咯也可以通过逐步交叉偶联方法制备。以交叉偶联和定向锂化为关键反应，实现了片层蛋白O、P、Q和R的全合成。 (c) 2007 Elsevier Ltd. 保留所有权利。
Palladium-catalyzed Suzuki-Miyaura Coupling of N-benzenesulfonyl-3,4-dibromopyrrole with a variety of arylboronic acids gave the corresponding 3,4-diarylpyrroles in high yields. The 3,4-differentially arylated pyrroles could also be prepared by stepwise cross-coupling approach. The total syntheses of lamellarins O, P, Q, and R have been achieved by using the cross-coupling and the directed lithiation as key reactions. (c) 2007 Elsevier Ltd. All rights reserved.