Role of IFN-gamma in allograft rejection.
Role of IFN-gamma in allograft rejection.
复制标题
DOI：
10.1615/critrevimmunol.v22.i4.50
复制
发表时间：
2002
影响因子：
1.3
通讯作者：
L. Hidalgo;P. Halloran
中科院分区：
文献类型：
--
作者：
L. Hidalgo;P. Halloran
干扰素(IFN)- γ是一种主要由活化的T细胞和NK细胞产生的细胞因子，对免疫和非免疫细胞具有复杂的作用。ifn - γ在炎症中发挥重要作用，通常与其他细胞因子协同作用，如il -1 β和tnf - α。ifn - γ的独特之处在于它能够在许多组织中诱导主要组织相容性复合体（MHC）的表达，使其与移植特别相关。在缺乏ifn - γ的情况下，移植物排斥反应的结果表明，ifn - γ调节但不是异体反应所必需的，抑制CTL的产生。在体内，ifn - γ在对血管化器官同种异体移植的早期反应中具有保护作用：当ifn - γ不可用时，小鼠移植有发生坏死的倾向，显然是由于微循环衰竭。ifn - γ的缺乏大大降低了同种异体器官移植中MHC的诱导，这可能与ifn - γ的保护作用间接相关。然而，ifn - γ在移植过程后期也会促进移植物血管疾病。因此，ifn - γ对同种异体器官移植存活具有多种且可能相互矛盾的影响，既作用于免疫系统，也作用于移植物本身，其净效应取决于移植物类型和移植后的时间。
Interferon (IFN)-gamma is a cytokine produced mostly by activated T cells and NK cells that has complex effects on immune and nonimmune cells. IFN-gamma plays important roles in inflammation, usually in synergy with other cytokines, such as IL-1beta and TNF-alpha. The uniqueness of IFN-gamma lies in its ability to induce major histocompatibility complex (MHC) expression in many tissues, making it particularly relevant to transplantation. The results of graft rejection in the absence of IFN-gamma show that IFN-gamma modulates but is not essential for the allogeneic responses, suppressing generation of CTL. In vivo IFN-gamma has a protective role early in the response to vascularized organ allografts: transplants in mice have a tendency to develop necrosis when IFN-gamma is not available, apparently by failure of the microcirculation. The lack of IFN-gamma greatly reduces the induction of MHC in organ allografts, and it is possible that this is indirectly related to the protective effect of IFN-gamma. Nevertheless IFN-gamma also promotes graft vessel disease later in the course ofthe transplant. Thus IFN-gamma has diverse and potentially contradictory effects on organ allograft survival, acting both on the immune system and on the graft itself, the net effect depending on the graft type and the time post-transplant.