Audiological abnormalities in patients with vitiligo
Audiological abnormalities in patients with vitiligo
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DOI：
10.1111/j.1365-2230.2005.02004.x
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发表时间：
2006-01-01
影响因子：
4.1
通讯作者：
Tunali, S
中科院分区：
文献类型：
--
作者：
Aydogan, K;Turan, OF;Tunali, S
背景资料。越来越多的证据表明，白癜风是一种影响整个色素系统的全身性疾病。目的探讨白癜风患者听觉系统含黑色素细胞成分的亚临床异常。对57例活动期白癜风患者和50例正常人进行了常规测听和脑干听觉诱发反应(BAERS)检查。比较两组间I、III、V潜伏期及I-III、III-V、I-V波峰间潜伏期(IPL)。8例白癜风患者有轻度感音神经性听力减退(14%)，而对照组未发现异常听力学结果(P=0.006)。与对照组比较，双耳第三峰潜伏期延长(P=0.008.0 2，P=0.0 1)，IPL I-III峰潜伏期延长(P=0.0 4，P=0.0 5)，右耳第五峰潜伏期延长(P=0.0 4)，其他潜伏期和IPL无明显差异。黑色素可能在建立和/或维持听觉系统的结构和功能中发挥重要作用，并可能调节内耳对听觉刺激的转导。
Background. Accumulating evidence suggests that vitiligo is a systemic disease affecting the entire pigmentary system.Aim. To investigate the subclinical abnormalities of melanin-containing cellular elements of the auditory system in patients with vitiligo.Methods. We studied the conventional audiometric investigations and brainstem auditory evoked responses (BAERs) of 57 active patients with vitiligo and 50 healthy human subjects. The I, III and V latencies, and I-III, III-V and I-V interpeak latencies (IPL) between the groups were compared.Results. A mild degree of sensorineural hypoacusis was found in eight patients with vitiligo (14%), whereas no controls demonstrated abnormal audiological results (P = 0.006). A statistically significant increase in both ears of the third peak latency (P = 0.02, P = 0.01, respectively) and IPL I-III (P = 0.04, P = 0.008, respectively), and a significant increase of the fifth peak latency in the right ear (P = 0.04) were found, compared with controls, but no differences were found for other latencies and IPLs.Conclusions. Melanin may play a significant role in the establishment and/or maintenance of the structure and function of the auditory system and may modulate the transduction of the auditory stimuli by the inner ear.