Affective temperaments across the bipolar-unipolar spectrum: Examination of the TEMPS-A in 927 patients and controls
Affective temperaments across the bipolar-unipolar spectrum: Examination of the TEMPS-A in 927 patients and controls
复制标题
DOI：
10.1016/j.jad.2009.09.020
复制
发表时间：
2010-06-01
影响因子：
6.6
通讯作者：
Smith, Daniel J.
中科院分区：
文献类型：
--
作者：
Di Florio, Arianna;Hamshere, Marian;Smith, Daniel J.
目的：目前，人们对使用情绪性气质作为双相情感障碍的中间表型非常感兴趣。然而，这一领域的许多文献是相互矛盾的。本研究的目的是在迄今927名受试者的最大样本中检验情感气质得分的梯度假设，该得分由孟菲斯、比萨、巴黎和圣地亚哥的气质评估量表(TEMPS-A)测量，从双相情感障碍I型(BP-I)到双相情感障碍II型(BP-II)、复发性抑郁症(MDD-R)和对照组(CG)。方法：使用非参数检验比较诊断组之间的TEMPS-A得分，并使用多因素Logistic回归检验Temps-A得分与诊断的相关性，同时控制当前的情绪状态。结果：尽管BP-II组在几个TEMPS-A子量表上的得分高于BP-I组和MDD-R组，但在控制混杂变量后，这些差异并不显著。MDD-R组和对照组之间的恶劣心境分量表和焦虑分量表有所不同。限制：横断面设计不允许我们评估潜在的纵向气质评分变化，只能通过自填式问卷进行评估。结论：我们没有发现情感气质评分存在梯度的证据。与对照组相比，单相和双相患者都报告了较高的恶劣心境得分，这可能支持了对双相-单相抑郁的单一看法。在未来的研究中，考虑到潜在的混杂因素将是重要的，这些研究试图将情绪性气质作为基因研究的中间表型。(C)2009爱思唯尔B.V.保留所有权利。
Objective: There is currently a great deal of interest in the use of affective temperaments as possible intermediate phenotypes for bipolar disorder. However, much of the literature in this area is conflicting. Our aims were to test the hypothesis of a gradient in affective temperament scores, as measured by the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A), from bipolar disorder type I (BP-I), through bipolar disorder type II (BP-II), recurrent major depressive disorder (MDD-R), and a control group (CG) in the largest sample to date of 927 subjects.Methods: Non parametric tests were used to compare TEMPS-A scores between diagnostic groups and multinomial logistic regression was used to test the association between TEMPS-A scores and diagnosis while controlling for current mood state, age and gender.Results: Although the BP-II group scored higher than the BP-I and MDD-R groups on several TEMPS-A subscales, these differences were not significant when confounding variables were controlled for. The dysthymic subscale differentiated between affected and controls and the anxious subscale differentiated the MDD-R group from controls.Limitations: The cross-sectional design did not allow us to evaluate potential longitudinal changes of temperament scores, which were assessed only with a self-report questionnaire.Conclusion: We failed to find evidence of a gradient in affective temperament scores. Both unipolar and bipolar patients reported high dysthymic scores relative to controls, perhaps supporting a unitary view of depression across the bipolar-unipolar spectrum. Taking account of potential confounders will be important in future studies which seek to use affective temperaments as intermediate phenotypes in genetic research. (C) 2009 Elsevier B.V. All rights reserved.