DISTRIBUTION OF TOXAPHENE, DDT, AND PCB AMONG LIPOPROTEIN FRACTIONS IN RAT AND HUMAN PLASMA
DISTRIBUTION OF TOXAPHENE, DDT, AND PCB AMONG LIPOPROTEIN FRACTIONS IN RAT AND HUMAN PLASMA
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DOI：
10.1007/bf01971836
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发表时间：
1990-01-01
影响因子：
6.1
通讯作者：
SLANINA, P
中科院分区：
文献类型：
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作者：
MOHAMMED, A;EKLUND, A;SLANINA, P
用大鼠和人血浆研究了~(14)C-毒杀芬、~(14)C-滴滴涕和~(14)C-多氯联苯在体内和体外脂蛋白组分中的分布。在体外和体内实验中，这些物质与大鼠血浆组分的联系是相似的。总放射性的37%到52%与富含胆固醇的高密度脂蛋白(HDL2，d=1.075-1.21g/ml)有关，18%-52%的放射性与富含白蛋白的底层部分(BF，d>；1.21g/ml)有关。在活体研究中，还观察到放射性从脂蛋白组分到BF的随时间变化的重新分布。在人的血浆中，这三种化合物的分布是不同的，并且与各个脂蛋白组分的胆固醇水平无关。毒杀芬在血糖(d>；1.21ml)、高密度脂蛋白(d=1.063-1.21g/m l)和低密度脂蛋白(d=1.006-1.063 g/m l)中的分布几乎相等(分别为26%、27%和29%)，而极低密度脂蛋白(d<；1.006)只有18%。相比之下，大部分DDT和多氯联苯放射性在BF中恢复(分别为52%和62%)，而只有38%-48%存在于脂蛋白部分。讨论了外源物质与血浆脂蛋白相互作用的复杂性。
The distribution of 14C-toxaphene, 14C-DDT, and 14C-PCB among lipoprotein fractions was studied in vitro and in vivo using rat and human plasma. The association of these substances with rat plasma fractions was similar in both in vitro and in vivo experiments. Thirty-seven to fifty-two per cent of the total radioactivity was associated with the cholesterol-rich high density lipoproteins (HDL2, d = 1.075-1.21 g/ml) and 18-52% was recovered in the albumin-rich bottom fraction (BF, d > 1.21 g/ml). A time-dependent redistribution of the radioactivity from the lipoprotein fractions to the BF was also observed in the in vivo studies. In human plasma, the distribution of the three compounds was different and uncorrelated to the cholesterol level of the individual lipoprotein fractions. Toxaphene was almost equally distributed between BF (d > 1.21 ml), HDL (d = 1.063-1.21 g/ml) and low density lipoproteins (LDL, d = 1.006-1.063 g/ml) (26%, 27% and 29%, respectively), while only 18% appeared in the very low density lipoprotein (VLDL, d < 1.006) fraction. In contrast, a large proportion of DDT and PCB radioactivity was recovered in the BF (52% and 62%, respectively) while only 38-48% was present in lipoprotein fractions. The complex nature of the interaction between xenobiotics and plasma lipoproteins is discussed.