Pitavastatin: Protection against neuronal retinal damage induced by ischemia-reperfusion injury in rats
Pitavastatin: Protection against neuronal retinal damage induced by ischemia-reperfusion injury in rats
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DOI：
10.1080/02713680701649603
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发表时间：
2007-11-01
影响因子：
2
通讯作者：
Tanihara, Hidenobu
中科院分区：
文献类型：
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作者：
Kawaji, Takahiro;Inomata, Yasuya;Tanihara, Hidenobu
目的：观察匹伐他汀对缺血再灌注损伤大鼠视网膜神经元损伤的保护作用。方法与结果：采用高眼压诱导Sprague-Dawley大鼠缺血再灌注损伤。匹伐他汀（0.1、0.5或1.0 mg/kg）分别在缺血再灌注损伤诱导前12小时或5分钟，或诱导后12小时或24小时静脉给予。形态计量学和逆行标记分析显示，匹伐他汀（0.5 mg/kg）在诱导缺血再灌注损伤前5分钟，甚至在缺血再灌注损伤后12小时和24小时给予神经保护作用。这些效应取决于剂量；匹伐他汀浓度为0.5和1mg /kg时有保护作用，但0.1 mg/kg时没有。此外，预给药匹伐他汀（0.5 mg/kg）可降低缺血再灌注损伤后12和24小时p -选择素和细胞间粘附分子-1的表达。结论：匹伐他汀有预防视网膜神经病变的作用
Purpose: To evaluate the neuroprotective effects of pitavastatin against neuronal retinal damage induced by ischemia-reperfusion injury in rats. Methods and Results: Ischemia-reperfusion injury was induced in Sprague-Dawley rats using ocular hypertension. Pitavastatin (0.1, 0.5, or 1.0 mg/kg) was given intravenously 12 hr or 5 min before, or 12 or 24 hr after the induction of ischemia-reperfusion injury. Morphometric and retrograde labeling analyses revealed neuroprotective effects when pitavastatin (0.5 mg/kg) was administered 5 min before-even 12 and 24 hr-after induction of ischemia-reperfusion injury. These effects depended on dose; protection was noted at pitavastatin concentrations of 0.5 and 1 mg/kg but not 0.1 mg/kg. Furthermore, preadministration of pitavastatin (0.5 mg/kg) reduced expression of P-selectin and intercellular adhesion molecule-1 at 12 and 24 hr after induction of ischemia-reperfusion injury. Conclusions: As pitavastatin was efficacious in preventing retinal neuronal