Design, synthesis, and biological evaluation of a highly water-soluble psoralen-based photosensitizer.
Design, synthesis, and biological evaluation of a highly water-soluble psoralen-based photosensitizer.
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DOI：
10.1016/j.bmc.2017.02.050
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发表时间：
2017-04
影响因子：
3.5
通讯作者：
Yoshiyuki Uruma;Takuya Nonomura;Priscilla Yoong Mei Yen;Marie Edatani;Ryo Yamamoto;K. Onuma;F. Okada
中科院分区：
文献类型：
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作者：
Yoshiyuki Uruma;Takuya Nonomura;Priscilla Yoong Mei Yen;Marie Edatani;Ryo Yamamoto;K. Onuma;F. Okada
近年来，光动力疗法(PDT)已被批准用于治疗包括癌症在内的各种疾病。PDT是一种使用一种特殊药物的治疗方法，称为光敏剂，它与特定的光源一起作用。这个医疗行业的增长正在扩大，因为它是治疗癌症的另一个有希望的替代方案，减轻了患者的治疗负担。这包括微创程序的好处，以及在靶向突变方面提供高精度。近二十年来，癌症研究人员在开发光敏剂方面取得了令人瞩目的研究成果，这些光敏剂可以增强对癌症生物学和遗传学的理解。不幸的是，并不是所有的PDT都能像其他深度治疗那样起到同样的作用，因为PDT有各种局限性，比如当光敏剂在体内停留较长时间时，PDT会导致光敏反应。在本论文中，我们的研究重点是合成一种可提高检测癌细胞效率的高可溶性光敏剂。
In recent years, photodynamic therapy (PDT) has been approved for treating various medical conditions, including cancer. PDT is a treatment that employs a particular drugs, called photosensitizers which work along with specific light source. The growth of this medical industry is expanding as it is another promising alternative to treat cancer which lessen the burden of treatments in patients. This includes the benefits of minimally invasive procedures and delivering high accuracy in targeting mutations. In recent two decades, cancer researchers have produced remarkable studies on developing photosensitizers that enhance understanding of biology and genetics of cancer. It is unfortunate that not all PDT can work as well as other profound treatment because PDT has various limitations like PDT leads photosensitivity reaction that arises when the photosensitizer remains in the body for a long period of time. In this paper, our studies centers on synthesizing a highly soluble photosensitizing agent with improved effectiveness on detecting cancer cells.