Comparison of salivary and serum glucose levels in diabetic patients.
Comparison of salivary and serum glucose levels in diabetic patients.
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DOI：
10.1177/1932296814552673
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发表时间：
2015-01-01
影响因子：
5
通讯作者：
Sharma, Deepti
中科院分区：
文献类型：
--
作者：
Gupta, Shruti;Sandhu, Simarpreet Virk;Sharma, Deepti
糖尿病是一种非传染性疾病，在全世界和发展中国家的发病率不断上升。用于检测葡萄糖水平的最常用的诊断生物流体是血液，但样本收集是一种侵入性和痛苦的过程。因此，需要一种无创和无痛的技术来检测葡萄糖水平。本研究的目的是估计唾液的葡萄糖水平，评估血清和唾液葡萄糖水平之间是否存在任何显着相关性，并将唾液葡萄糖水平与糖尿病持续时间、年龄和性别相关。本文用葡萄糖氧化酶法测定了200例受试者（100例糖尿病患者和100例非糖尿病患者）的血清和唾液葡萄糖水平。还在随机选择的40名糖尿病受试者中测量了糖化血红蛋白水平。本研究的结果显示，唾液和血清葡萄糖水平之间的显着相关性在糖尿病和非糖尿病受试者。糖尿病患者和非糖尿病患者的唾液葡萄糖水平与性别或年龄之间以及糖尿病患者的唾液葡萄糖水平与糖尿病持续时间之间均无显著相关性。根据这些发现，可以得出结论，唾液葡萄糖水平可以作为一种潜在的非侵入性辅助监测糖尿病患者的血糖控制。
Diabetes mellitus is a noncommunicable disease with a rising prevalence worldwide and in developing countries. The most commonly used diagnostic biofluid for detection of glucose levels is blood, but sample collection is an invasive and painful procedure. Thus, there arises a need for a noninvasive and painless technique to detect glucose levels. The objectives of the present study were to estimate the glucose levels of saliva, to assess if any significant correlation existed between the serum and salivary glucose levels, and to correlate salivary glucose levels with regard to duration of diabetes, age, and gender. In the present study, serum and salivary glucose levels of 200 subjects (100 diabetic subjects and 100 nondiabetic subjects) were estimated by glucose oxidase method. Glycosylated hemoglobin levels were also measured in randomly selected 40 diabetic subjects. The findings of present study revealed a significant correlation between salivary and serum glucose levels in both diabetic and nondiabetic subjects. No significant relationship was observed between salivary glucose levels and gender or age in both diabetics and nondiabetics and between salivary glucose levels and duration of diabetes in diabetics. On the basis of the findings, it was concluded that salivary glucose levels could serve as a potentially noninvasive adjunct to monitor glycemic control in diabetic patients.