Effect of lanthanum on catecholamine release from adrenal medulla
Effect of lanthanum on catecholamine release from adrenal medulla
复制标题
镧对肾上腺髓质释放儿茶酚胺的影响
DOI：
10.1016/0024-3205(72)90134-8
复制
发表时间：
1972
期刊：
影响因子：
6.1
通讯作者：
J. Borowitz
中科院分区：
文献类型：
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作者：
J. Borowitz
首次将分离的牛肾上腺暴露于镧（0.5 mM）中会导致显著的儿茶酚胺释放。随后将腺体暴露于镧（0.5 mM）会导致很少的儿茶酚胺释放，但对乙酰胆碱的反应抑制了74%，对钾的反应抑制了44%。镧对钙的动员可能解释了肾上腺初次暴露于镧时的释放。镧对钙进入髓细胞的抑制可能解释了乙酰胆碱诱导或钾诱导的儿茶酚胺释放的抑制。
The first exposure of isolated bovine adrenals to lanthanum (0.5 mM) causes a marked catecholamine release. Subsequent exposure of the glands to lanthanum (0.5 mM) causes very little catecholamine release but does inhibit the response to acetylcholine by 74% and the response to potassium by 44%. Calcium mobilization by lanthanum probably explains the release upon the initial exposure of adrenals to lanthanum. Inhibition of calcium entry into the medullary cells by lanthanum may explain the inhibition of acetylcholine-induced or potassium-induced catecholamine release.