Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population
Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population
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DOI：
10.1210/jc.2009-1465
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发表时间：
2010-03-01
影响因子：
5.8
通讯作者：
Lam, Karen S. L.
中科院分区：
文献类型：
--
作者：
Cheung, Chloe Y. Y.;Tso, Annette W. K.;Lam, Karen S. L.
内容：最近的大规模全基因组关联研究发现了与肥胖和身体质量指数（BMI）相关的新的遗传变异，除了已被充分描述的FTO和MC 4 R遗传变异外。目的：本研究旨在检测13个先前报道的肥胖和/或BMI相关基因座与中国人肥胖的关联。设计和研究参与者：这是一项横断面病例对照研究，包括470例肥胖患者（BMI ≥ 27.5 kg/m2）和700例正常体重对照（18.5 kg/m2
Context: Recent large-scale genome-wide association studies identified novel genetic variants associated with obesity and body mass index (BMI) in addition to the well-described FTO and MC4R genetic variants.Objective: This study aimed to examine 13 previously reported obesity and/or BMI-associated loci for associations with obesity in Chinese.Design and Study Participants: This was a cross-sectional case-control study in 470 obese cases (BMI >= 27.5 kg/m(2)) and 700 normal-weight controls (18.5