Iptakalim Enhances Adult Mouse Hippocampal Neurogenesis Via Opening Kir6.1‐Composed K‐ATP Channels Expressed in Neural Stem Cells
Iptakalim Enhances Adult Mouse Hippocampal Neurogenesis Via Opening Kir6.1‐Composed K‐ATP Channels Expressed in Neural Stem Cells
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DOI：
10.1111/j.1755-5949.2012.00359.x
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发表时间：
2012-09
影响因子：
5.5
通讯作者：
Jing-Zhe Yang;Xu Huang;Fang-Fang Zhao-Fang;Qiang Xu;Gang Hu
中科院分区：
文献类型：
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作者：
Jing-Zhe Yang;Xu Huang;Fang-Fang Zhao-Fang;Qiang Xu;Gang Hu
新出现的证据表明，刺激成人神经发生为中枢神经系统疾病提供了新的策略。埃他卡林（Ipt）是一种新型的ATP敏感性钾（K-ATP）通道开放剂，在体内和体外均被证实具有多潜能的神经保护作用。然而，Ipt是否能调节成体神经发生仍不清楚。
Emerging evidence indicates that stimulating adult neurogenesis provides novel strategies for central nervous system diseases. Iptakalim (Ipt), a novel ATP‐sensitive potassium (K‐ATP) channel opener, has been demonstrated to play multipotential neuroprotective effects in vivo and in vitro. However, it remains unknown whether Ipt could regulate the adult neurogenesis.