Evaluation of hypochlorous acid washes in the treatment of chronic venous leg ulcers.
Evaluation of hypochlorous acid washes in the treatment of chronic venous leg ulcers.
复制标题
次氯酸冲洗治疗慢性腿部静脉溃疡的评价。
DOI：
10.12968/jowc.2006.15.1.26861
复制
发表时间：
2006
影响因子：
1.9
通讯作者：
M. Hughes
中科院分区：
文献类型：
--
作者：
J. Selkon;G. Cherry;J. Wilson;M. Hughes
目的
次氯酸（HOCl）是一种高度杀微生物剂，对细菌、病毒和真菌具有活性。使用定量微生物学，初步研究表明，它实现了慢性下肢静脉溃疡细菌负荷的明显减少。该研究旨在确定它是否可以作为常规治疗未愈合的慢性静脉溃疡的额外治疗方法。
方法
在先前报告的基础上，我们设计了一项研究，其中患者作为其自身对照，其中仅标准治疗（加压包扎）未能实现伤口尺寸减小44%的患者接受HOCl冲洗。
结果
在接受研究的30名患者中，10名在标准治疗三周后溃疡减少了44%。除了标准压迫治疗外，其余20名患者在12周内接受HOCl冲洗。在20个溃疡中，9个（45%）愈合，5个（25%）尺寸缩小超过60%。所有患者均无疼痛。
结论
这些发现证实了次氯酸冲洗治疗下肢静脉溃疡的临床疗效。使用HOCl冲洗作为顽固性下肢静脉溃疡的连续治疗可明显增加愈合并迅速缓解疼痛。
OBJECTIVE
Hypochlorous acid (HOCl) is a highly microbiocidal agent active against bacteria, viruses and fungi. Using quantitative microbiology, preliminary studies showed it achieved an appreciable reduction in the bacterial burden in chronic venous leg ulcers. The study aimed to determine whether it has a role as an additional treatment for chronic venous ulcers that have not healed with conventional treatment.
METHOD
On the basis of previous reports we designed a study in which patients acted as their own controls, in that only patients who failed to achieve a 44% reduction in wound size with standard treatment (compression bandaging) received HOCl washes.
RESULTS
Of 30 patients admitted to the study, 10 achieved a 44% ulcer reduction after three weeks of standard treatment. In addition to the standard compression treatment, the remaining 20 patients were given HOCl washes over 12 weeks. Of the 20 ulcers, nine (45%) healed and five (25%) reduced in size by over 60%. All patients became free of pain.
CONCLUSION
These findings confirm the clinical efficacy of treating venous leg ulcers with hypochlorous washes. Use of HOCl washes as an adjunctive therapy for recalcitrant venous leg ulcers appreciably increases healing and rapidly relieves pain.