A comparison of RSV and influenza in vitro kinetic parameters reveals differences in infecting time
A comparison of RSV and influenza in vitro kinetic parameters reveals differences in infecting time
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DOI：
10.1371/journal.pone.0192645
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发表时间：
2018-02-08
期刊：
影响因子：
3.7
通讯作者：
Dobrovolny, Hana M.
中科院分区：
文献类型：
--
作者：
Gonzalez-Parra, Gilberto;De Ridder, Filip;Dobrovolny, Hana M.
流感和呼吸道合胞病毒（RSV）引起急性呼吸道感染。由于这两种病毒都会导致症状相似的疾病，研究人员经常试图将从一种病毒研究中获得的知识应用于另一种病毒。这对于理解病毒动力学或制定治疗策略可能是一种有效和高效的策略，但前提是我们充分了解两种病毒之间的异同。本研究采用数学模型定量比较体外RSV和流感病毒感染的病毒动力学。具体而言，我们确定了RSV A2和3株流感病毒，A/WSN/33 (H1N1), A/Puerto Rico/8/1934 （H1N1）和H1N1大流行性流感病毒的病毒动力学参数。我们发现RSV病毒滴度的上升速度较慢，达到峰值的时间比流感病毒晚。我们的分析表明，RSV病毒滴度的缓慢增加是由于病毒从一个细胞到另一个细胞的缓慢传播引起的。这些结果提供了流感病毒和RSV之间动态差异的估计，并有助于深入了解病毒与宿主的相互作用，这种相互作用导致两种疾病在患者中观察到的病程差异。
Influenza and respiratory syncytial virus (RSV) cause acute infections of the respiratory tract. Since the viruses both cause illnesses with similar symptoms, researchers often try to apply knowledge gleaned from study of one virus to the other virus. This can be an effective and efficient strategy for understanding viral dynamics or developing treatment strategies, but only if we have a full understanding of the similarities and differences between the two viruses. This study used mathematical modeling to quantitatively compare the viral kinetics of in vitro RSV and influenza virus infections. Specifically, we determined the viral kinetics parameters for RSV A2 and three strains of influenza virus, A/WSN/33 (H1N1), A/Puerto Rico/8/1934 (H1N1), and pandemic H1N1 influenza virus. We found that RSV viral titer increases at a slower rate and reaches its peak value later than influenza virus. Our analysis indicated that the slower increase of RSV viral titer is caused by slower spreading of the virus from one cell to another. These results provide estimates of dynamical differences between influenza virus and RSV and help provide insight into the virus-host interactions that cause observed differences in the time courses of the two illnesses in patients.