Incidence of clinically diagnosed systemic lupus erythematosus 1992-1998 using the UK General Practice Research Database
Incidence of clinically diagnosed systemic lupus erythematosus 1992-1998 using the UK General Practice Research Database
复制标题
DOI：
10.1002/pds.1199
复制
发表时间：
2006-09-01
影响因子：
2.6
通讯作者：
de Vries, Corinne S.
中科院分区：
文献类型：
--
作者：
Nightingale, Alison L.;Farmer, Richard D. T.;de Vries, Corinne S.
目的分析1992年1月1日至1998年12月31日中国全科医学研究数据库（GPRD）中系统性红斑狼疮（SLE）的发病率及其性别特征。病例必须在首次诊断日期前至少有3年的记录数据。结果共确诊SLE患者390例，发病率（IR）为3.02/10万/年（CI 95 2.72，3.32）。有41名男性（IR 0.65/100000/年（CI 95 0.45，0.85））和349名女性（IR 5.30/100000/年（CI 95 4.75，5.86））。男性和女性诊断时的中位年龄分别为54岁和46岁，发病率高峰在30-69岁的女性中。女性与男性的发病率比为8.15（CI 95 5.9，11.6）。结论这是第一个英国范围内的SLE发病率的研究。这项研究的结果与之前在诺丁汉和伯明翰进行的小型研究一致。虽然在GPRD中记录的SLE症状并不完整，但我们得出结论，可以成功识别偶发病例，因为病历中通常有支持诊断的证据。版权所有（c）2006约翰威利父子有限公司。
Purpose To determine the age- and sex-specific incidence rates of systemic lupus erythematosus (SLE) in the population of the General Practice Research Database (GPRD) between 1.1.1992 and 31.12.1998.Methods We searched the GPRD for incident cases of clinically diagnosed SLE with supporting evidence of diagnosis in their medical record. Cases must have had at least 3 years of data in their record prior to date of first diagnosis. We calculated the annual and age- and sex-specific incidence rates of SLE.Results We identified 390 incident cases of SLE yielding an incidence rate (IR) of 3.02/100000/year (CI95 2.72,3.32). There were 41 males (IR 0.65/100000/year (CI95 0.45, 0.85)) and 349 females (IR 5.30/100000/year (CI95 4.75, 5.86)). The median age at diagnosis for males and females was 54 and 46 years, respectively, and the peak incidence rates were amongst women aged 30-69 years. The incidence rate ratio for females to males was 8.15 (CI95 5.9, 11.6).Conclusions This is the first UK-wide study of the incidence of SLE. The results of this study are consistent with previous smaller studies conducted in Nottingham and Birmingham. Although recording of symptoms of SLE is not complete in the GPRD, we conclude that incident cases can be successfully identified because generally there is supporting evidence of diagnosis in medical record. Copyright (c) 2006 John Wiley & Sons, Ltd.