Immune globulin for intravenous use: enhancement of in vitro opsonophagocytic activity of neonatal serum.
Immune globulin for intravenous use: enhancement of in vitro opsonophagocytic activity of neonatal serum.
复制标题
静脉内使用的免疫球蛋白：增强新生儿血清的体外调理吞噬活性。
DOI：
10.1093/infdis/151.2.217
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Baker,CJ
中科院分区：
文献类型：
--
作者：
Givner,LB;Edwards,MS;Anderson,DC;Baker,CJ
Neonates born with less-than-protective levels of transplacentally derived specific antibody are at risk for the development of disease due to type III, group BStreptococcus(III-GBS). The effect of immune serum globulin modified for intravenous use (MISG) on in vitro opsonophagocytosis of III-GBS was evaluated. Cord blood was obtained from 13 healthy, full-term neonates, and bactericidal activity for III-GBS was measured. Before the addition of MISG, one of three serum specimens with moderate levels of antibody to III-GBS, and eight of 10 specimens with low antibody levels demonstrated no bactericidal activity. The mean bactericidal index increased from 27.1% before the addition of MISG to 96.5% with MISG added in a volume equal to that of serum. The effect of MISG on opsonophagocytosis decreased with its dilution in buffer, and no effect was shown at dilutions ⩾1:4. Thus, MISG can substantially increase in vitro opsonophagocytosis of III-GBS in sera from newborns.
