Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York.
Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York.
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DOI：
10.7916/d8sj1jb5
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发表时间：
1998-06
期刊：
影响因子：
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通讯作者：
S. Stellman;M. Djordjevic;J. Muscat;L. Gong;David L. Bernstein;Marc L. Citron;A. White;M. Kemeny;E. Busch;A. Nafziger
中科院分区：
文献类型：
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作者：
S. Stellman;M. Djordjevic;J. Muscat;L. Gong;David L. Bernstein;Marc L. Citron;A. White;M. Kemeny;E. Busch;A. Nafziger
一些有机氯农药（OCPs）和多氯联苯作为乳腺癌的可能风险因素正在接受调查，因为它们具有雌激素特性并且广泛存在于环境中。重要的是要知道一些研究者使用的脂肪组织和其他人使用的血清测定是否可以提供关于身体负荷的可比信息。在纽约长岛（一个高风险地区）进行的乳腺癌环境因素病例对照研究中，测量了293名妇女脂肪组织和血清中7种有机氯农药或其分解产物以及14种多氯联苯同系物的浓度。使用作者开发的超临界流体萃取方法测量脂肪OCP/PCB水平。在所有脂肪和血清样本中均检测到1，1-二氯-2，2-二（4-氯苯基）乙烯（p，p '-DDE）;在至少92%的脂肪样本中检测到两种氯代环己烷衍生物-β-六氯环己烷（一种林丹异构体）和六氯苯。在所有脂肪样本和98%以上的血清样本中检测到二邻位六氯多氯联苯同系物2，4，5，2 '，4'，5 '-六氯联苯和2，3，4，2'，4 '，5'-六氯联苯。1，1-二氯-2，2-二（4-氯苯基）乙烯在脂肪和血清中分别占总农药残留量的77%和71%。2，4，5，2 '，4'，5 '-六氯联苯在脂肪中占24%，在血清中占21%。14种多氯联苯同系物的相对浓度模式与其他人类研究报告的模式相似，也是各种生物群（包括哺乳动物和鸟类）环境样本报告的典型模式，但与职业接触工人报告的模式有很大差异。所有脂肪血清相关性农药和大多数多氯联苯的统计学显着。各种环境有机氯化合物的血清或脂肪OCP/PCB水平可作为有用的生物标志物的身体负担。
Some organochlorine pesticides (OCPs) and PCBs are under investigation as possible risk factors for breast cancer because of their estrogenic properties and widespread presence in the environment. It is important to know whether adipose tissue used by some investigators and serum assays used by others can provide comparable information on body burden. Concentrations of seven OCPs or their breakdown products as well as 14 PCB congeners were measured in the adipose tissue and serum of 293 women enrolled as controls in a case-control study of environmental factors for breast cancer in Long Island, New York, a high-risk region. Adipose OCP/PCB levels were measured using a supercritical fluid extraction method developed by the authors. 1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene (p,p'-DDE) was detected in all adipose and serum samples; two chlordane derivatives, beta-hexachlorocyclohexane (a lindane isomer) and hexachlorobenzene, were detected in at least 92% of adipose samples. The di-ortho hexachlorinated PCB congeners 2,4,5,2',4',5'-hexachlorobiphenyl and 2,3,4,2',4',5'-hexachlorobiphenyl were detected in all adipose and over 98% of serum samples. 1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene comprised 77% of total pesticide residues in adipose and 71% in serum. 2,4,5,2',4',5'-Hexachlorobiphenyl comprised 24% of adipose and 21% of serum PCBs. The relative concentration patterns of the 14 PCB congeners were similar to those reported in other human studies and were also typical of patterns reported in environmental samples from various biota, including mammals and birds, but differed substantially from patterns reported in occupationally exposed workers. All adipose-serum correlations for pesticides and most PCBs were statistically significant. Either serum or adipose OCP/PCB levels of a variety of environmental organochlorine compounds may serve as useful biomarkers of body burden.