Seminal influences: Drosophila Acps and the molecular interplay between males and females during reproduction.
Seminal influences: Drosophila Acps and the molecular interplay between males and females during reproduction.
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DOI：
10.1093/icb/icm046
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发表时间：
2007-09
影响因子：
2.6
通讯作者：
K. Ravi Ram;M. Wolfner
中科院分区：
文献类型：
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作者：
K. Ravi Ram;M. Wolfner
成功的繁殖需要雄性和雌性的共同贡献。在果蝇中，雄性的贡献包括附腺蛋白(ACPs)，这是精液的成分。ACP一旦转移到雌性体内，就会影响雌性的生理和行为。虽然ACP基因的初级序列在物种和属之间表现出差异，但精液中蛋白质生化类的保守意味着功能的保守。近年来，生物信息学与果蝇可用的分子和遗传工具相结合，将ACPs的功能分析扩展到基因组/蛋白质组的规模。ACP与雌性之间的分子相互作用提高了雌性的产卵量，降低了雌性的获得性，改变了雌性的免疫反应和取食行为，促进了雌性精子的储存和利用，并影响了雌性的寿命。在这里，我们提供了黑腹葡萄球菌ACPs的概述，并综合了几项研究的结果，这些研究使目前已知的黑腹葡萄球菌ACPs的数量达到了112个。然后，我们讨论了几个例子，说明ACPs和雌性之间的相互作用是如何调节雌性的生理过程和行为的。了解ACP如何引起特定的雌性反应将提供对生殖生物学和化学交流的见解、分析性合作和/或性冲突模式的工具，以及可能有助于控制虫害战略的信息。
Successful reproduction requires contributions from both the male and the female. In Drosophila, contributions from the male include accessory gland proteins (Acps) that are components of the seminal fluid. Upon their transfer to the female, Acps affect the female's physiology and behavior. Although primary sequences of Acp genes exhibit variation among species and genera, the conservation of protein biochemical classes in the seminal fluid suggests a conservation of functions. Bioinformatics coupled with molecular and genetic tools available for Drosophila melanogaster has expanded the functional analysis of Acps in recent years to the genomic/proteomic scale. Molecular interplay between Acps and the female enhances her egg production, reduces her receptivity to remating, alters her immune response and feeding behavior, facilitates storage and utilization of sperm in the female and affects her longevity. Here, we provide an overview of the D. melanogaster Acps and integrate the results from several studies that bring the current number of known D. melanogaster Acps to 112. We then discuss several examples of how the female's physiological processes and behaviors are mediated by interactions between Acps and the female. Understanding how Acps elicit particular female responses will provide insights into reproductive biology and chemical communication, tools for analyzing models of sexual cooperation and/or sexual conflict, and information potentially useful for strategies for managing insect pests.