Hypoglycemia, frailty and dementia in older people with diabetes: Reciprocal relations and clinical implications
Hypoglycemia, frailty and dementia in older people with diabetes: Reciprocal relations and clinical implications
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DOI：
10.1016/j.jdiacomp.2016.07.027
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发表时间：
2016-11-01
影响因子：
3
通讯作者：
Sinclair, Alan J.
中科院分区：
文献类型：
--
作者：
Abdelhafiz, Ahmed H.;McNicholas, Emily;Sinclair, Alan J.
低血糖、虚弱和痴呆之间的关系似乎是相互的，并可能导致恶性循环。虚弱似乎是增加低血糖和痴呆风险的关键因素，引发了相互关系。体重减轻可能是身体虚弱的潜在危险因素。许多体弱的老年糖尿病患者似乎有不必要的严格血糖控制，正在接受降糖药物治疗，这可能会增加低血糖的风险。随着患者年龄的增长，体重明显减轻，应审查其血糖目标，并应考虑减少甚至停用降糖药物。(C)2016 Elsevier Inc. All rights reserved.
The relationships between hypoglycemia, frailty and dementia appear to be reciprocal and can lead to a vicious circle. Frailty appears to be a crucial factor increasing the risk for both hypoglycemia and dementia, initiating the reciprocal relationships. Weight loss is likely to be the underlying risk factor for frailty. Many frail older people with diabetes seem to have unnecessarily tight glycemic control, being treated with hypoglycemic medications that likely increase the risk of hypoglycemia. As patients get older with significant weight loss their glycemic targets should be reviewed, and reduction or even withdrawal of their hypoglycemic medications should be considered. (C) 2016 Elsevier Inc. All rights reserved.