Soluble receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin in ankylosing spondylitis: OPG is associated with poor physical mobility and reflects systemic inflammation
Soluble receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin in ankylosing spondylitis: OPG is associated with poor physical mobility and reflects systemic inflammation
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DOI：
10.1007/s10067-010-1543-y
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发表时间：
2010-10-01
影响因子：
3.4
通讯作者：
Chou, Chung-Tei
中科院分区：
文献类型：
--
作者：
Chen, Chun-Hsiung;Chen, Hung-An;Chou, Chung-Tei
本研究旨在探讨核因子-kappa B受体激活剂配体(RANKL)和护骨素(OPG)在强直性脊柱炎(AS)发病中的作用。测定42例强直性脊柱炎患者和26例健康体检者血清可溶性RANKL(SRANKL)和OPG水平。我们评估了AS患者的疾病活动度、功能能力、总体评估和身体活动，并检测了全身炎症指标、血沉(ESR)和C反应蛋白(CRP)水平。42例AS患者血清sRANKL[平均值(SD)为4.751.88比3.70(1.14)pmol/L，P=0.015]和OPG[平均值(SD)5.18(1.19)比4.52(0.85)pmol/L，P=0.026]显著高于26例健康对照组。有趣的是，血清OPG水平与血沉(r=0.417，p=0.007)、C反应蛋白(r=0.524，p<；0.001)、耳屏至壁距(r=0.556，p<；；与改良肖伯指数(r=-0.525，p=0.001)、颈椎旋转(r=-0.403，p=0.022)、腰椎侧屈(r=-0.587，p<0.00)、胸围(r=-0.553p<0.001)呈负相关。此外，在血清OPG水平较高(千分之4.925pmol/L，n=21)的AS患者中，患者的耳屏到壁距离(p=0.007)、指尖到地板距离(p=0.023)和C-反应蛋白(p=0.014)水平显著增加，而改良的Schober指数(p=0.012)、腰椎侧屈(p=0.019)和胸部扩张(p=0.005)显著降低。AS患者血清sRANKL和OPG水平升高，可能参与AS的发病过程。OPG的产生与身体活动能力差有关，可能反映了AS的全身性炎症。
The objective of the study was to investigate the role of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) in ankylosing spondylitis (AS). Serum levels of soluble RANKL (sRANKL) and OPG were measured in 42 AS patients and 26 healthy controls. We evaluated the AS patient's disease activity, functional ability, global assessment, and physical mobility and tested markers of systemic inflammation, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels. Serum levels of sRANKL [mean (SD), 4.75 (1.88) vs. 3.70 (1.14) pmol/l, p = 0.015] and OPG [mean (SD), 5.18 (1.19) vs. 4.52 (0.85) pmol/l, p = 0.026] were significantly higher in the 42 AS patients than the 26 healthy controls. Interestingly, serum OPG levels correlated significantly with ESR (r = 0.417, p = 0.007), CRP (r = 0.524, p < 0.001), tragus-to-wall distance (r = 0.556, p < 0.001), fingertip-to-floor distance (r = 0.423, p = 0.007), and occiput-to-wall distance (r = 0.465, p = 0.002) and correlated inversely with modified Schober index (r = -0.525, p = 0.001), cervical rotation (r = -0.403, p = 0.022), lateral lumbar flexion (r = -0.587, p < 0.001), and chest expansion (r = -0.553, p < 0.001). Moreover, in the AS patients with higher (a parts per thousand yen4.925 pmol/l, n = 21) serum OPG levels, there were significant increases in the tragus-to-wall distance (p = 0.007), fingertip-to-floor distance (p = 0.023), and CRP levels (p = 0.014) and decreased in the modified Schober index (p = 0.012), lateral lumbar flexion (p = 0.019), and chest expansion (p = 0.005). Serum levels of sRANKL and OPG are increased in the AS patients and may participate in the disease process of AS. Production of OPG has association with poor physical mobility and may reflect systemic inflammation in AS.