Multiregional 1H-MRSI of the hippocampus, thalamus, and basal ganglia in schizophrenia
Multiregional 1H-MRSI of the hippocampus, thalamus, and basal ganglia in schizophrenia
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DOI：
10.1007/s00406-003-0398-5
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发表时间：
2003-02-01
影响因子：
4.7
通讯作者：
Henn, FA
中科院分区：
文献类型：
--
作者：
Ende, G;Braus, DF;Henn, FA
背景海马、丘脑和基底节是精神分裂症的主要研究区域。目的本研究的目的是证实以前的研究结果减少N-乙酰天冬氨酸在海马和丘脑区域，并探讨可能的代谢产物的变化，在壳核精神分裂症。方法对13例稳定服药的精神分裂症患者和年龄匹配的健康对照者进行丘脑、基底节和海马的MRSI研究。结果与对照组相比，患者海马区和丘脑中的N-乙酰天门冬氨酸信号减少，但壳核中的N-乙酰天门冬氨酸信号没有减少。在海马区和壳核中，肌酸和磷酸肌酸以及含胆碱化合物的信号无显著组间差异，但在患者的丘脑中，含胆碱化合物的信号降低。结论精神分裂症患者基底节的代谢过程与海马和丘脑的代谢过程相反。
Background The hippocampus, thalamus and basal ganglia are among the brain regions of major interest in schizophrenia. Aims The purpose of this study was to corroborate previous findings of reduced N-acetylaspartate in the hippocampal and thalamic regions and to investigate possible metabolite changes in the putamen in schizophrenia. Method MRSI study of the thalamus, basal ganglia, and hippocampus in 13 schizophrenic patients under stable medication and age-matched healthy controls. Results A decrease of the N-acetylaspartate signal was found in the hippocampal region and the thalamus but not in the putamen of patients compared to controls. No significant group differences in the signals from creatine and phosphocreatine, and choline-containing compounds were found in the hippocampal region and the putamen but the signal from choline-containing compounds was decreased in the thalamus of patients. Conclusion Metabolic processes in the basal ganglia of schizophrenic patients seem to be opposite the hippocampal and thalamus findings.