Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder
Altered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder
复制标题
首发重度抑郁症患者背外侧前额叶皮质功能连接的改变
DOI：
10.1016/j.ejrad.2011.04.058
复制
发表时间：
2012-12-01
影响因子：
3.3
通讯作者：
Shan, Baoci
中科院分区：
文献类型：
--
作者：
Ye, Ting;Peng, Jing;Shan, Baoci
背景资料：本研究旨在探讨首发抑郁症（MDD）患者右侧背外侧前额叶皮层（DLPFC）静息态功能连接的改变。扫描静息态功能磁共振图像和结构磁共振图像。基于体素形态测量（VBM）的结果进行功能连接分析。选择右侧DLPFC作为种子感兴趣区（ROI），其灰质密度（GMD）在MDD患者中较对照组降低，且与汉密尔顿抑郁量表（HDRS）评分呈负相关。与健康对照组相比，MDD患者与左侧背侧前扣带皮层（ACC）右侧DLPFC的功能连接增加，左侧海马旁回（PHG）、丘脑和中央前回。结论：应用VBM结果进行功能连接分析，提示右侧DLPFC的GMD异常可能与MDD病理生理中的功能连接改变有关，这可能有助于进一步表征MDD的结构-功能关系。(C)由Elsevier爱尔兰有限公司出版。
Background: The aim of this study was to investigate resting-state functional connectivity alteration of the right dorsolateral prefrontal cortex (DLPFC) in patients with first-episode major depressive disorder (MDD).Methods: Twenty-two first-episode MDD patients and thirty age-, gender-and education-matched healthy control subjects were enrolled. Rest state functional magnetic resonance images and structure magnetic resonance images were scanned. The functional connectivity analysis was done based on the result of voxel-based morphometry (VBM). And the right DLPFC was chosen as the seed region of interests (ROI), as its gray matter density (GMD) decreased in the MDD patients compared with controls and its GMD values were negative correlation with the Hamilton Depression Rating Scale (HDRS) scores.Results: Compared to healthy controls, the MDD patients showed increased functional connectivity with right the DLPFC in the left dorsal anterior cingulate cortex (ACC), left parahippocampal gyrus (PHG), thalamus and precentral gyrus. In contrast, there were decreased functional connectivity between the right DLPFC and right parietal lobe.Conclusions: By applying the VBM results to the functional connectivity analysis, the study suggested that abnormality of GMD in right DLPFC might be related to the functional connectivity alteration in the pathophysiology of MDD, which might be useful in further characterizing structure-function relations in this disorder. (C) 2012 Published by Elsevier Ireland Ltd.