Association Between Calcineurin Inhibitor Treatment and Peripheral Nerve Dysfunction in Renal Transplant Recipients
Association Between Calcineurin Inhibitor Treatment and Peripheral Nerve Dysfunction in Renal Transplant Recipients
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DOI：
10.1111/ajt.12324
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发表时间：
2013-09-01
影响因子：
8.8
通讯作者：
Krishnan, A. V.
中科院分区：
文献类型：
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作者：
Arnold, R.;Pussell, B. A.;Krishnan, A. V.
神经毒性是用于预防实体器官移植排斥反应的免疫抑制治疗的一个重要的临床副作用。这项研究旨在为肾移植后接受免疫抑制治疗的患者神经毒性的潜在机制提供见解。对38例肾移植后免疫抑制患者、19例接受钙调神经磷酸酶抑制剂(CNI)治疗的患者和19例接受无钙调神经磷酸酶(CNI)治疗的患者进行了临床和神经生理学评估。两组在年龄、性别、移植后时间和肾功能方面匹配，并与正常对照组(n=20)进行比较。CNI组的神经兴奋性参数有显著差异，提示神经膜去极化(p
Neurotoxicity is a significant clinical side effect of immunosuppressive treatment used in prophylaxis for rejection in solid organ transplants. This study aimed to provide insights into the mechanisms underlying neurotoxicity in patients receiving immunosuppressive treatment following renal transplantation. Clinical and neurophysiological assessments were undertaken in 38 patients receiving immunosuppression following renal transplantation, 19 receiving calcineurin inhibitor (CNI) therapy and 19 receiving a calcineurin-free (CNI-free) regimen. Groups were matched for age, gender, time since transplant and renal function and compared to normal controls (n=20). The CNI group demonstrated marked differences in nerve excitability parameters, suggestive of nerve membrane depolarization (p