Measurement of temporal regional cerebral perfusion with single-photon emission tomography predicts rate of decline in language function and survival in early Alzheimer’s disease
Measurement of temporal regional cerebral perfusion with single-photon emission tomography predicts rate of decline in language function and survival in early Alzheimer’s disease
复制标题
用单光子发射断层扫描测量颞区脑灌注可预测早期阿尔茨海默病的语言功能下降率和生存率
DOI：
--
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
W. van Gool
中科院分区：
文献类型：
--
作者：
J. Claus;G. Walstra;A. Hijdra;E. V. van Royen;B. Verbeeten Jr.;W. van Gool
抽象。我们确定了单光子发射断层扫描（SPET）测量的局部脑血流量（rCBF）与阿尔茨海默病认知功能下降和生存率之间的关系。在一项前瞻性随访研究中，69例连续转诊的早期可能阿尔茨海默病（NINCDS/ADRDA标准）患者在初步诊断时使用锝-99标记的六甲基丙烯胺肟进行SPET。在基线和6个月后评估神经心理功能，并获得所有患者的生存数据，延长至5.5年的随访。6个月后左颞下叶（P<0.01）和左顶叶（P<0.01）rCBF与语言功能下降显著相关。采用考克斯比例风险回归分析，左颞叶rCBF与生存率之间的相关性也具有统计学意义（P<0.05）。通过四分位数分析，发现左颞叶rCBF低（rCBF<73.7%，P<0.01）和死亡风险高的阈值效应。在最低的四分位数中，中位生存时间为2.7年（随访至5.2年），而其他四分位数为4.4年（随访至5.5年）。Kaplan-Meier生存曲线显示左颞部rCBF最低四分位数与其他四分位数的生存曲线具有统计学显著性（P<0.05，对数秩检验）。所有结果均不受年龄、性别、痴呆严重程度、症状持续时间、教育程度和局部皮质萎缩评级调整的影响。我们的结论是，左颞部rCBF预测语言功能下降和早期可能阿尔茨海默病患者的生存率，低rCBF和高风险的死亡率的阈值效应。
Abstract. We determined the relationship between regional cerebral blood flow (rCBF) measured with single-photon emission tomography (SPET) and decline in cognitive function and survival in Alzheimer’s disease. In a prospective follow-up study, 69 consecutively referred patients with early probable Alzheimer’s disease (NINCDS/ADRDA criteria) underwent SPET performed at the time of initial diagnosis using technetium-99m-labelled hexamethylpropylene amine oxime. Neuropsychological function was assessed at baseline and after 6 months and survival data were available on all patients, extending to 5.5 years of follow-up. Lower left temporal (P<0.01) and lower left parietal (P<0.01) rCBF were statistically significantly related to decline in language function after 6 months. The association between left temporal rCBF and survival was also statistically significant (P<0.05) using Cox proportional hazards regression analysis. Performing analysis with quartiles of the distribution, we found a threshold effect for low left temporal rCBF (rCBF<73.7%, P<0.01) and high risk of mortality. In this lowest quartile, median survival time was 2.7 years (follow-up to 5.2 years), compared with 4.4 years in the other quartiles (follow-up to 5.5 years). Kaplan-Meier survival curves showed statistically significant (P<0.05, log rank test) survival curves for the lowest versus other quartiles of left temporal rCBF. All results were unaffected by adjustment for age, sex, dementia severity, duration of symptoms, education and ratings of local cortical atrophy. We conclude that left temporal rCBF predicts decline in language function and survival in patients with early probable Alzheimer’s disease, with a threshold effect of low rCBF and high risk of mortality.
登录
查看更多内容
阿尔茨海默氏病局部脑血流量的认知相关性。
影响因子：
--
作者：
Eberling,JL;Reed,BR;Baker,MG;Jagust,WJ
通讯作者：
Jagust,WJ
DOI：
10.1001/jama.1997.03540340047031
发表时间：
1997-03-12
影响因子：
120.7
作者：
Snowdon, DA;Greiner, LH;Markesbery, WR
通讯作者：
Markesbery, WR
单光子发射计算机断层扫描的颞叶灌注可预测阿尔茨海默病的认知能力下降速度。
影响因子：
--
作者：
Wolfe,N;Reed,BR;Eberling,JL;Jagust,WJ
通讯作者：
Jagust,WJ
Iofetamine I 123 单光子发射计算机断层扫描可准确诊断阿尔茨海默病。
影响因子：
--
作者：
Johnson,KA;Holman,BL;Rosen,TJ;Nagel,JS;English,RJ;Growdon,JH
通讯作者：
Growdon,JH