Phase-tuned neuronal firing encodes human contextual representations for navigational goals.
Phase-tuned neuronal firing encodes human contextual representations for navigational goals.
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DOI：
10.7554/elife.32554
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发表时间：
2018-06-22
期刊：
影响因子：
7.7
通讯作者：
Jacobs J
中科院分区：
文献类型：
--
作者：
Watrous AJ;Miller J;Qasim SE;Fried I;Jacobs J
We previously demonstrated that the phase of oscillations modulates neural activity representing categorical information using human intracranial recordings and high-frequency activity from local field potentials (Watrous et al., 2015b). We extend these findings here using human single-neuron recordings during a virtual navigation task. We identify neurons in the medial temporal lobe with firing-rate modulations for specific navigational goals, as well as for navigational planning and goal arrival. Going beyond this work, using a novel oscillation detection algorithm, we identify phase-locked neural firing that encodes information about a person’s prospective navigational goal in the absence of firing rate changes. These results provide evidence for navigational planning and contextual accounts of human MTL function at the single-neuron level. More generally, our findings identify phase-coded neuronal firing as a component of the human neural code.
