Validation of four-dimensional computed tomography without external reference respiratory signals for radiation treatment planning of lung tumors
Validation of four-dimensional computed tomography without external reference respiratory signals for radiation treatment planning of lung tumors
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DOI：
10.1088/2057-1976/ac8555
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发表时间：
2022-09-01
影响因子：
1.4
通讯作者：
Toya，Ryo
中科院分区：
文献类型：
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作者：
Doi，Yasuhiro;Shimohigashi，Yoshinobu;Toya，Ryo
无器械四维（4D）计算机断层扫描（CT）允许从六个特征采集呼吸信号，而无需外部器械进行电影CT处理。该方法最近已被引入肺肿瘤的放射治疗计划中。为了验证无设备4D CT，必须将其与需要外部监测设备的传统4D CT进行比较。我们比较了两种方法，使用多细胞4D体模，模拟患者的运动在呼吸过程中的目标体积（TV），目标位置（TP），和内部电视肺肿瘤放射治疗。我们回顾性地获得了10例接受肺肿瘤放射治疗计划的患者的图像，并比较了两种方法，如在体模研究中。对于体模研究，两种方法之间的平均TV、TP的均方根误差和平均内部TV差异范围分别为− 4.5%至1.2%、0.7至2.6 mm和− 1.1%至3.4%。临床研究的相应结果范围分别为-1.5%至14.9%、0.1至5.9 mm和-9.7%至10.1%。除了目标运动和高偏移外，无器械4D CT的临床研究结果与传统4D CT的结果一致。因此，无设备4D CT可以替代传统的4D CT用于肺肿瘤的放射治疗计划。
Deviceless four-dimensional (4D) computed tomography (CT) allows the acquisition of respiratory signals from six features without requiring an external device for cine CT processing. This method has been recently introduced in radiation treatment planning of lung tumors. To validate deviceless 4D CT, it must be compared with conventional 4D CT, which requires an external monitoring device. We compared the two methods using a multicell 4D phantom that simulates patient's movement during respiration regarding the target volume (TV), target position (TP), and internal TV for lung tumor radiation therapy. We retrospectively obtained images of 10 patients who underwent radiation treatment planning of lung tumors and compared the two methods, as in the phantom study. For the phantom study, the mean TV, root mean square errors of the TP, and mean internal TV differences between the two methods ranged from− 4.5% to 1.2%, 0.7 to 2.6 mm, and− 1.1% to 3.4%, respectively. The corresponding results of the clinical study ranged from− 1.5% to 14.9%, 0.1 to 5.9 mm, and− 9.7% to 10.1%, respectively. The results of deviceless 4D CT for the clinical study were consistent with those of conventional 4D CT, except for target movements with high excursions. Therefore, deviceless 4D CT can be an alternative to conventional 4D CT for radiation treatment planning of lung tumors.