POSITRON EMISSION TOMOGRAPHY DEMONSTRATES DOPAMINE-D2 RECEPTOR SUPERSENSITIVITY IN THE STRIATUM OF PATIENTS WITH EARLY PARKINSONS-DISEASE
POSITRON EMISSION TOMOGRAPHY DEMONSTRATES DOPAMINE-D2 RECEPTOR SUPERSENSITIVITY IN THE STRIATUM OF PATIENTS WITH EARLY PARKINSONS-DISEASE
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DOI：
10.1002/mds.870050114
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发表时间：
1990-01-01
影响因子：
8.6
通讯作者：
RUOTSALAINEN, U
中科院分区：
文献类型：
--
作者：
RINNE, UK;LAIHINEN, A;RUOTSALAINEN, U
用正电子发射断层扫描技术对7例早期帕金森病患者用[11C]-拉氯普利进行了体内纹状体多巴胺D2受体结合的研究。患者均有单侧症状，均未接受过左旋多巴治疗。[11C]-莱克洛必利在纹状体的蓄积迅速，在注射后约40分钟达到稳定状态。测量纹状体和小脑中[11C]-雷氯普利的结合量：计算两个半球的纹状体总放射性，并计算各自的纹状体/小脑比值。帕金森病症状对侧大脑半球纹状体/小脑[11C]-拉氯必利结合比值显著高于对侧(p<；0.01)。因此，本研究证明早期帕金森病患者存在多巴胺D2受体结合的失神经超敏反应。
Striatal dopamine D2receptor binding was studied in vivo with positron emission tomography in seven patients with early Parkinson's disease using [11C]–raclopride. The patients had unilateral symptoms and none of them had received levodopa treatment. The accumulation of [11C]–raclopride in the striatum was rapid and reached a steady state at approximately 40 min after injection. The binding of [11C]–raclopride was measured in the striatum and cerebellum: The total striatal radioactivity in both hemispheres was counted and the respective striatum/cerebellum ratios were calculated. The striatum/cerebellum ratio of [11C]–raclopride binding was significantly (p < 0.01) increased in the hemisphere contralateral to the parkinsonian symptoms as compared with the opposite hemisphere. Thus, this study demonstrates that there is denervation supersensitivity in dopamine D2receptor binding in early Parkinson's disease.