Serum zinc and copper levels in children with chronic renal failure
Serum zinc and copper levels in children with chronic renal failure
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DOI：
10.1007/s00467-006-0119-1
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发表时间：
2006-08-01
影响因子：
3
通讯作者：
Haddadi, Marzieh
中科院分区：
文献类型：
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作者：
Esfahani, Seyed Taher;Hamidian, Mohammad Reza;Haddadi, Marzieh
我们评估了两组慢性肾功能衰竭（CRF）儿童-定期血液透析（第1组，n = 40）和保守治疗（第2组，n = 31）的CRF儿童-和一组健康儿童（第3组，n = 30）的血清锌（Zn）和铜（Cu）水平的变化。所有的参与者在研究5 - 18岁之间，三组的组成几乎相同的年龄和性别。第1组儿童接受血液透析的时间在3至52个月之间（平均：20.97 +/- 14.8个月）。为了评估透析时间对血清锌水平的影响，我们将第1组患者进一步分为两个亚组：A亚组（n = 20）患者接受血液透析治疗少于18个月（平均：8.85 ± 4.83个月）;亚组B患者（n = 20）接受血液透析治疗超过18个月（平均：33.1 ± 10.86个月）。采用质子激发X射线荧光分析（PIXE）方法对样品中的微量元素进行了分析。结果如下：血液透析组患儿血清锌水平明显低于非透析组和健康儿童组（P < 0.001），但两组间无显著性差异。三组间血清铜水平无显著差异。B亚组血清锌水平低于A亚组（P < 0.001）。相关性检验表明，儿童血液透析时间与血清锌水平呈负线性关系。结论：慢性血液透析可导致CRF患儿血清中某些微量元素水平异常，其严重程度随血液透析时间的延长而加重。缺乏这些微量元素，特别是锌，可能会导致接受慢性血液透析的儿童出现各种疾病和症状。
We evaluated changes in serum zinc ( Zn) and copper ( Cu) levels in two groups of children with chronic renal failure ( CRF) - children with CRF who were on regular hemodialysis ( Group 1, n = 40) and children with CRF who were on conservative management ( Group 2, n = 31) - and in one group of healthy children ( Group 3, n = 30). All of the participants in the study were between 5 18 years old, and the composition of the three groups was almost identical with respect to age and sex. The length of time the children in Group 1 had been on hemodialysis varied between 3 and 52 months ( mean: 20.97 +/- 14.8 months). To evaluate the impact of the duration of dialysis on serum levels of Zn, we further sub-divided Group 1 patients into two subgroups: Subgroup A patients ( n = 20) had been on hemodialysis therapy for less than 18 months ( mean: 8.85 +/- 4.83 months); Subgroup B patients ( n = 20) had been on hemodialysis therapy for longer than 18 months ( mean: 33.1 +/- 10.86 months). The PIXE ( proton-induced X-ray emission) was used for measuring the trace elements. Results: The mean serum level of Zn was lower in the Group 1 ( hemodialysis group) children than in the children of Group 2 ( on conservative management) and group 3 ( healthy children) ( p < 0.001), but the difference was not significant between Groups 2 and 3. No significant differences in serum levels of Cu were found among the three groups. The serum level of Zn was lower in Subgroup B than in Subgroup A ( p < 0.001). The correlation test showed that there was an inverse linear relation between the length of time the child was on the hemodialysis regimen and serum Zn levels. Conclusion: Chronic hemodialysis may lead to abnormalities in the serum levels of some trace elements in children with CRF that increase in severity with increasing duration of hemodialysis. Deficiencies of these trace elements - zinc in particular may contribute to various conditions and symptoms in children undergoing chronic hemodialysis.