A Randomized Trial of Objective Spectacle Prescriptions for Adults with Down Syndrome: Baseline Data and Methods.
A Randomized Trial of Objective Spectacle Prescriptions for Adults with Down Syndrome: Baseline Data and Methods.
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DOI：
10.1097/opx.0000000000001631
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Trast KR
中科院分区：
文献类型：
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作者：
Anderson HA;Benoit JS;Marsack JD;Manny RE;Ravikumar A;Fern KD;Trast KR
使用常规临床技术很难确定对唐氏综合症患者最有效的屈光矫正。优化该人群眼镜矫正的新客观方法可以通过提高视觉质量来减少日常生活的限制。本手稿描述了国家眼科研究所资助的一项临床试验中研究参与者的方法和基线特征，该临床试验旨在评估患有唐氏综合症的成人的客观眼镜矫正效果。还报告了主要结果测量（远视力）的会话间可重复性。患有唐氏综合症的成年人参加了一项 9 次访问研究，以比较临床衍生的眼镜矫正和根据波前像差数据衍生的两种不同的客观眼镜矫正。眼镜矫正是随机进行的，每次进行两个月。远视力是用贝利-洛维式图表测量的。视力的会话间可重复性是通过对第 1 次和第 2 次访视时习惯性矫正获得的双眼视力测量结果进行差异与平均值分析来确定的。b 纳入了 30 名患有大范围屈光不正的成年人（平均±标准差年龄 = 29±10 岁）。第 1 次就诊时视力下降（右眼：0.47 ± 0.20 logMAR，左眼：0.42 ± 0.17 logMAR）。访视 1 和 2 之间的平均差异为 0.02 ± 0.06 logMAR，重复性系数（受试者标准偏差内的 1.96 x）为 0.12 logMAR。本研究旨在探讨确定光学矫正的新策略，以减少唐氏综合症患者常见的视力缺陷。本研究（6 个字母）中发现的视力良好的会话间重复性表明，尽管存在视力下降，但患有唐氏综合症的成人可靠地执行了该临床试验的结果测量。
It is difficult to determine the most efficacious refractive correction for individuals with Down syndrome using routine clinical techniques. New objective methods that optimize spectacle corrections for this population may reduce limitations on daily living by improving visual quality. This manuscript describes the methods and baseline characteristics of study participants in a National Eye Institute sponsored clinical trial to evaluate objectively derived spectacle corrections in adults with Down syndrome. Inter-session repeatability of the primary outcome measure (distance visual acuity) is also reported. Adults with Down syndrome were enrolled into a 9 visit study to compare clinically derived spectacle corrections and two different objective spectacle corrections derived from wavefront aberration data. Spectacle corrections were randomized and dispensed for two months each. Distance visual acuity was measured with a Bailey-Lovie style chart. Inter-session repeatability of acuity was established by performing difference versus mean analysis from binocular acuity measures obtained through habitual corrections at visits 1 and 2.b Thirty adults (mean ± standard deviation age = 29 ± 10 years) with a large range of refractive errors were enrolled. Presenting visual acuity at visit 1 was reduced (right eye: 0.47 ± 0.20 logMAR, left eye: 0.42 ± 0.17 logMAR). The mean difference between visits 1 and 2 was 0.02 ± 0.06 logMAR with a coefficient of repeatability (1.96 x within subject standard deviation) of 0.12 logMAR. This study seeks to investigate new strategies to determine optical corrections that may reduce commonly observed visual deficits in individuals with Down syndrome. The good inter-session repeatability of acuity found in this study (6 letters) indicates that, despite the presence of reduced acuity, adults with Down syndrome performed the outcome measure for this clinical trial reliably.