Comparisons of the outcomes on control, type of management and complications status in early onset and late onset type 2 diabetes in Asia
Comparisons of the outcomes on control, type of management and complications status in early onset and late onset type 2 diabetes in Asia
复制标题
DOI：
10.1016/j.diabres.2005.05.007
复制
发表时间：
2006-02-01
影响因子：
5.1
通讯作者：
Yeo, JP
中科院分区：
文献类型：
--
作者：
Chuang, LM;Soegondo, S;Yeo, JP
目的：描述亚洲早发（EOD）和晚发 2 型糖尿病（LOD）的临床特征和慢性糖尿病并发症。 研究设计和方法：以纸质形式回顾性收集信息（患者基本数据、糖尿病、高血压、血脂异常接受的治疗、临床测量、并发症、生活方式管理等），并前瞻性收集用于 HbA(1c) 评估的血样。使用非参数回归和逻辑回归分析平均值、比例和相关因素。结果：EOD（< 30 年）的频率在不同的亚洲国家有所不同（0.4-5.3%）。超重（BMI > 23 kg/m(2)）在 EOD (60%) 和 LOD (66%) 中都很常见。 EOD 的特点是 HbA(1c)（中位值 8.9% 对 7.9%）和 FPG（中位值 9.8 mmol/L 对 8.3 mmol/L）水平显着升高，但高血压不太常见（43% 对 59%）。两组患者的脂质谱（胆固醇和甘油三酯）相似。白内障在 LOD 中更为常见，并且与发病年龄和糖尿病病程有关，而晚期眼病的发生率则增加。 EOD 队列中发现了视网膜病变和光凝病史。结论：除了糖尿病控制和疾病持续时间外，发病年龄还增加了 2 型糖尿病人群发生某些慢性并发症的风险。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Objective: To describe the clinical characteristics and chronic diabetic complications in early (EOD) and late onset type 2 diabetes mellitus (LOD) in Asia.Research design and methods: Retrospective collection of information (basic patient data, treatment received for diabetes, hypertension, dyslipidaemia, clinical measurements, complications, life-style management, etc.) on paper form and prospective collection of blood samples for HbA(1c) assessment were performed. Means, proportions and associated factors were analyzed using non-parametric and logistic regression.Results: The frequency of EOD (< 30 years) varies in different Asian countries (0.4-5.3%). Overweight (BMI > 23 kg/m(2)) was common in both EOD (60%) and LOD (66%). EOD was characterized by significantly higher levels of HbA(1c) (median 8.9% versus 7.9%) and FPG (median 9.8 mmol/L versus 8.3 mmol/L) but hypertension was less common (43% versus 59%). Lipid profiles (cholesterol and triglycerides) were similar between both groups of patients. Cataract was more common in LOD and was associated with onset age and diabetes duration whereas an increase in frequency of advanced eye disease. retinopathy and history of photocoagulation was found in EOD cohort.Conclusions: In addition to diabetic control and duration of the disease, the onset age conferred risk to certain subsets of chronic complications in type 2 diabetes population. (c) 2005 Elsevier Ireland Ltd. All rights reserved.