Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis.
Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis.
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DOI：
10.3390/cells10112808
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发表时间：
2021-10-20
期刊：
影响因子：
6
通讯作者：
Morrison AR
中科院分区：
文献类型：
--
作者：
Lee CF;Carley RE;Butler CA;Morrison AR
Coronary artery disease caused by atherosclerosis is a major cause of morbidity and mortality around the world. Data from preclinical and clinical studies support the belief that atherosclerosis is an inflammatory disease that is mediated by innate and adaptive immune signaling mechanisms. This review sought to highlight the role of Rac-mediated inflammatory signaling in the mechanisms driving atherosclerotic calcification. In addition, current clinical treatment strategies that are related to targeting hypercholesterolemia as a critical risk factor for atherosclerotic vascular disease are addressed in relation to the effects on Rac immune signaling and the implications for the future of targeting immune responses in the treatment of calcific atherosclerosis.
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