INCREASED PGE(2) FROM HUMAN MONOCYTES ISOLATED IN THE LUTEAL-PHASE OF THE MENSTRUAL-CYCLE - IMPLICATIONS FOR IMMUNITY
INCREASED PGE(2) FROM HUMAN MONOCYTES ISOLATED IN THE LUTEAL-PHASE OF THE MENSTRUAL-CYCLE - IMPLICATIONS FOR IMMUNITY
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DOI：
10.1016/0090-6980(94)90073-6
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发表时间：
1994-01-01
期刊：
影响因子：
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通讯作者：
DUBEY, DP
中科院分区：
文献类型：
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作者：
LESLIE, CA;DUBEY, DP
生殖激素与细胞和免疫反应中的性二型性有关。前列腺素（PG）是免疫应答的介质，其浓度和相对量对其影响至关重要。在从小鼠分离的常驻腹腔巨噬细胞中，我们先前注意到雌性细胞合成的PG显著多于雄性细胞。在这些实验中，我们研究了人类单核细胞中的PG代谢是否受性别和月经周期阶段的影响。从女性中分离的单核细胞，并在体外用LPS激活，平均产生比男性显着更多的PG到培养基中。在女性中，显着更多的PG被发现在培养基中分离的细胞在黄体期的周期比在早期卵泡期。也正是在这个黄体期，雌性与雄性有很大的不同。我们认为，在体内激素的变化与月经周期调节单核细胞合成的PG和其他免疫调节剂，如IL-1。这可能是理解男性和女性之间以及周期阶段内对免疫和炎症损伤的脆弱性差异的关键。
The reproductive hormones are implicated in the well documented sexual dimorphism in cellular and immune responses. Prostaglandins (PGs) are mediators of the immune response with their concentration and relative amounts being pivotal to their impact. In resident peritoneal macrophages isolated from mice we had previously noted that the cells from females synthesized significantly more PG than males. In these experiments we investigated whether PG metabolism in the human monocyte was influenced by gender and by stage of the menstrual cycle. Monocytes isolated from the female and activated in vitro with LPS produced on average significantly more PG into the medium than the males. Among females, significantly more PG was found in the medium from cells isolated during the luteal phase of the cycle than during the early follicular phase. It was also in this luteal phase in which the female differed substantially from males. We suggest that the in vivo hormonal changes associated with the menstrual cycle modulate monocyte synthesis of PG and other immune modulators such as IL-1. This could be a key to understanding differences in vulnerability between males and females as well as within phases of the cycle, to immune and inflammatory insult.