The quantitative potential for breast tomosynthesis imaging.
The quantitative potential for breast tomosynthesis imaging.
复制标题
乳腺断层合成成像的定量潜力。
DOI：
10.1118/1.3285038
复制
发表时间：
2010
期刊：
影响因子：
3.8
通讯作者：
Lo,JosephY
中科院分区：
文献类型：
--
作者：
Shafer,ChristinaM;Samei,Ehsan;Lo,JosephY
乳腺断层合成摄影由于其有限的角度扫描范围，在深度方向上的分辨率较低，这可能限制其量化组织密度的准确性。本研究使用相对简单的重建和图像处理算法评估乳房断层合成的定量潜力。这种定量可以改善病变的表征以及图像处理，以通过保留更多的低频信息来呈现具有乳腺X线摄影熟悉外观的断层合成图像。MethodsAll研究均基于西门子原型MAMMOMAT Novation TOMO乳腺断层摄影系统，总角度跨度为45°。这项调查是使用模拟和经验测量。使用乳腺断层合成几何结构和组织等效、均匀、体素化体模进行蒙特卡罗模拟，其中嵌入不同密度的立方体病变。然后使用在实际原型系统上成像的组织等效塑料体模进行实验研究。病变周围的材料被设置为脂肪等效或腺体等效塑料。从模拟实验中，散射的影响，病变深度，和背景材料密度进行了研究。实证实验研究了损伤深度、背景材料密度、X射线管能量和暴露水平的影响。此外，使用市售QA乳腺体模（CIRS型号11A）对拟定分析方法进行了独立评价。所有图像重建均采用滤波反投影算法。重建的体素值在每个切片进行了校正，以减少背景nonuniformities.ResultsThe所得的病变体素值与已知的腺体分数（相关系数）在所有模拟和经验条件下，包括独立的测试与QA幻影线性变化。对拟合线参数进行的方差分析显示，对于致密实验体模，两种不同背景材料之间以及28 kVp和剩余能量（26、30和32 kVp）之间存在统计学显著差异。然而，没有显着差异之间产生不同的能量的脂肪幻影，也没有任何其他组合的parameters.ConclusionsThese强的线性关系表明，乳腺断层合成图像体素值，经过我们概述的方法校正后，与真实的组织密度高度正相关。这种一致的线性意味着乳房断层合成成像确实具有定量的潜力。
PurposeDue to its limited angular scan range, breast tomosynthesis has lower resolution in the depth direction, which may limit its accuracy in quantifying tissue density. This study assesses the quantitative potential of breast tomosynthesis using relatively simple reconstruction and image processing algorithms. This quantitation could allow improved characterization of lesions as well as image processing to present tomosynthesis images with the familiar appearance of mammography by preserving more low‐frequency information.MethodsAll studies were based on a Siemens prototype MAMMOMAT Novation TOMO breast tomo system with a 45° total angular span. This investigation was performed using both simulations and empirical measurements. Monte Carlo simulations were conducted using the breast tomosynthesis geometry and tissue‐equivalent, uniform, voxelized phantoms with cuboid lesions of varying density embedded within. Empirical studies were then performed using tissue‐equivalent plastic phantoms which were imaged on the actual prototype system. The material surrounding the lesions was set to either fat‐equivalent or glandular‐equivalent plastic. From the simulation experiments, the effects of scatter, lesion depth, and background material density were studied. The empirical experiments studied the effects of lesion depth, background material density, x‐ray tube energy, and exposure level. Additionally, the proposed analysis methods were independently evaluated using a commercially available QA breast phantom (CIRS Model 11A). All image reconstruction was performed with a filtered backprojection algorithm. Reconstructed voxel values within each slice were corrected to reduce background nonuniformities.ResultsThe resulting lesion voxel values varied linearly with known glandular fraction (correlation coefficient ) under all simulated and empirical conditions, including for the independent tests with the QA phantom. Analysis of variance performed on the fit line parameters revealed statistically significant differences between the two different background materials and between 28 kVp and the remaining energies (26, 30, and 32 kVp) for the dense experimental phantom. However, no significant differences arose between different energies for the fatty phantom, nor for any of the many other combinations of parameters.ConclusionsThese strong linear relationships suggest that breast tomosynthesis image voxel values, after being corrected by our outlined methods, are highly positively correlated with true tissue density. This consistent linearity implies that breast tomosynthesis imaging indeed has potential to be quantitative.