Changing patterns of brain activation during category learning revealed by functional MRI
Changing patterns of brain activation during category learning revealed by functional MRI
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DOI：
10.1016/j.cogbrainres.2004.07.011
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发表时间：
2004-12-01
期刊：
影响因子：
--
通讯作者：
Thulborn, KR
中科院分区：
文献类型：
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作者：
Little, DM;Klein, R;Thulborn, KR
功能性磁共振成像 (fMRI) 用于研究正常人 (n=8) 中类别学习函数的神经变化。受试者接受连续 4 天的训练，将点图案分为四类。功能磁共振成像监测了训练前和仙人掌训练后学习过程中发生的变化。在功能磁共振成像过程中，受试者确定两种点图案是否属于同一类别。观察到由于训练而发生的行为变化，即在缩短的响应时间内响应准确性的提高。功能磁共振成像显示分布在已知视觉空间处理网络中的激活量最初增加。受学习影响的区域被确定为涉及眼球运动（额叶和辅助眼野，FEF 和 SEF）、空间注意力（顶上小叶和下顶小叶，SPL 和 IPL）以及视觉处理（初级、二级和三级视觉皮层）的规划和执行的区域。随着训练的进一步进展，激活量逐渐减少。在提出的两种学习机制中，即在给定网络上加强连接性和选择不同网络的机制，我们的数据支持前者。 (C) 2004 Elsevier B.V. 保留所有权利。
Functional magnetic resonance imaging (fMRI) was used to investigate neural changes as a function of category learning in normals (n=8). Subjects were trained to classify patterns of dots into four categories over 4 consecutive days. fMRI monitored the changes that occurred during learning prior to training and then following cacti training session. During fMRI, subjects determined whether two patterns of dots were members of the same category. The behavioral changes that Occurred as a result of the training were observed as increases in response accuracy within shortened response times. fMRI illustrated initial increases in volumes of activation distributed across the known visuospatial processing networks. The regions affected by learning were identified as those involved in the planning and execution of eye movements (frontal and supplementary eye fields, FEF and SEF), spatial attention (superior and inferior parietal lobules, SPL and IPL) and visual processing (primary, secondary, and tertiary Visual cortices). The volumes of activation then decreased as training progressed further. Of the two proposed mechanisms for learning, that of strengthened connectivity on a given network and that of selection of different networks, our data supports the former. (C) 2004 Elsevier B.V. All rights reserved.