Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities.
Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities.
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DOI：
10.1172/jci22147
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发表时间：
2004-06
期刊：
影响因子：
--
通讯作者：
B. Nickoloff;F. Nestle
中科院分区：
文献类型：
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作者：
B. Nickoloff;F. Nestle
皮肤和关节的慢性和过度炎症导致牛皮癣患者显着发病。作为一种流行的 T 淋巴细胞介导的疾病，牛皮癣及其治疗相关的副作用影响着全球患者。在这篇综述中，讨论了遗传学、免疫突触、细胞因子网络和信号通路的解开、异种移植模型以及选择性靶向治疗的日益使用等领域的最新进展。由于牛皮癣目前无法治愈，因此提出了新的管理策略来取代以前的偶然方法。这种从偶然发现到使用针对银屑病病变特定目标的新型选择性药物的战略转变正在迅速从研究台转移到患有这种慢性衰弱性疾病的患者的床边。
Chronic and excessive inflammation in skin and joints causes significant morbidity in psoriasis patients. As a prevalent T lymphocyte-mediated disorder, psoriasis, as well as the side effects associated with its treatment, affects patients globally. In this review, recent progress is discussed in the areas of genetics, the immunological synapse, the untangling of the cytokine web and signaling pathways, xenotransplantation models, and the growing use of selectively targeted therapies. Since psoriasis is currently incurable, new management strategies are proposed to replace previous serendipitous approaches. Such strategic transition from serendipity to the use of novel selective agents aimed at defined targets in psoriatic lesions is moving rapidly from research benches to the bedsides of patients with this chronic and debilitating disease.