Ganglion cells in colonic mucosa
Ganglion cells in colonic mucosa
复制标题
结肠粘膜神经节细胞
DOI：
10.1111/j.1440-1754.1990.tb01072.x
复制
发表时间：
1990
影响因子：
1.7
通讯作者：
J. Scurry
中科院分区：
文献类型：
--
作者：
J. Scurry
一般认为，粘膜内神经节细胞不存在于正常结肠中，只存在于慢性肠蠕动障碍、神经性肠发育不良中。在两例无神经性肠发育不良患者的内镜活检中偶然观察到两个粘膜内神经节细胞后，进行了一项回顾性研究，以确定神经节细胞在结肠粘膜中的出现频率。除指标病例外，在169例连续结肠活检中发现3个粘膜内神经节细胞。所有病例均通过过氧化物酶-抗过氧化物酶技术的神经元特异性烯醇化酶阳性染色证实神经节细胞的性质。所有患者均无神经性肠发育不良。神经性肠发育不良的诊断应依赖于一系列临床病理特征。罕见的粘膜内神经节细胞是正常的组织学发现。
Intramucosal ganglion cells are commonly believed not to occur in normal colon and to be found only in the chronic bowel motility disorder, neuronal intestinal dysplasia. After chance observations of two intramucosal ganglion cells in endoscopic biopsies in two patients without neuronal intestinal dysplasia, a retrospective study was undertaken to determine how frequently ganglion cells are present in colonic mucosa. Excluding the index cases, three intramucosal ganglion cells were found in 169 consecutive colonic biopsies. The nature of the ganglion cells was confirmed by positive neurone specific enolase staining by the peroxidase‐antiperoxidase technique in all cases. None of the patients had neuronal intestinal dysplasia. The diagnosis of neuronal intestinal dysplasia should rely on a constellation of clinicopathological features. Rare intramucosal ganglion cells are a normal histological finding.