HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression.
HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression.
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HOTAIR 通过结合内源性 miR-125 和 miR-143 在食管鳞状细胞癌进展中调节 HK2 表达
DOI：
10.18632/oncotarget.21195
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发表时间：
2017-10-17
期刊：
影响因子：
--
通讯作者：
Cao X
中科院分区：
文献类型：
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作者：
Ma J;Fan Y;Feng T;Chen F;Xu Z;Li S;Lin Q;He X;Shi W;Liu Y;Liu Z;Zhu B;Cao X
食管鳞状细胞癌（ESCC）是世界范围内最常见的恶性肿瘤之一，死亡率高。长链非编码RNA（LncRNA）在食管鳞癌中起着重要作用。LncRNA HOTAIR在ESCC中起重要的调节作用。我们强调HOTAIR可以通过直接结合miR-125和miR-143来影响ESCC中己糖激酶2（HK 2）表达的分子机制。总之，本研究鉴定了一种功能性lncRNA HOTAIR，其参与ESCC细胞中通过miRNA-125/miRNA-143-HK 2调节糖酵解。HOTAIR/miR-125和miR 143/HK 2相互作用的“竞争性内源性RNA”（ceRNA）模型可能成为ESCC诊断和治疗的重要靶点。
Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant cancers worldwide with a high death rate worldwide. Long non-coding RNA (LncRNA) has been recently demonstrated to play a critical role in ESCC. LncRNA HOTAIR played important regulatory roles in ESCC. We highlight the molecular mechanisms by which HOTAIR could influence the expression of Hexokinase 2 (HK2) in ESCC through binding miR-125 and miR-143 directly. Taken together, this study identified a functional lncRNA HOTAIR involved with regulation of glycolysis via miRNA-125/miRNA-143-HK2 in ESCC cells. The “competitive endogenous RNA” (ceRNA) model of HOTAIR/miR-125 and miR143/HK2 interaction might serve as important targets for ESCC diagnosis and therapy.